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别名 | CT99021 | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C22H18Cl2N8 |
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分子量 | 465.34 | CAS号 | 252917-06-9 | |
Solubility (25°C)* | 体外 | DMSO | 39 mg/mL (83.8 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Laduviglusib (CHIR-99021, CT99021)是一种GSK-3α和GSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。 | ||||
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靶点 |
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, Dr. Yong-Weon Yi from Georgetown University Medical Center
数据来源于[Data independently produced by , , Med Oncol, 2017, 35(1):7]
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Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts [ Bioact Mater, 2024, 31:463-474] | PubMed: 37701451 |
Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells [ Nat Commun, 2024, 15(1):2820] | PubMed: 38561332 |
Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range [ Adv Sci (Weinh), 2024, 11(3):e2304303] | PubMed: 37948328 |
Bento: a toolkit for subcellular analysis of spatial transcriptomics data [ Genome Biol, 2024, 25(1):82] | PubMed: 38566187 |
TEAD2 initiates ground-state pluripotency by mediating chromatin looping [ EMBO J, 2024, 10.1038/s44318-024-00086-5] | PubMed: 38605224 |
Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress [ J Nanobiotechnology, 2024, 22(1):132] | PubMed: 38532378 |
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue [ Cell Rep, 2024, 43(1):113616] | PubMed: 38150367 |
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids [ Oncogene, 2024, 43(3):155-170] | PubMed: 37985676 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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