Palbociclib

目录号：S4482 批次号：S448203

打印

化学数据

化学结构式 别名 PD 0332991 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C24H29N7O2
分子量 447.53 CAS号 571190-30-2
Solubility (25°C)* 体外 DMSO Insoluble
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Palbociclib (PD 0332991) 是一种高度特异性的 cyclin-dependent kinase 4 (Cdk4) 和 Cdk6 的抑制剂，IC50值分别为11 nM和16 nM。此产品溶解度不佳，动物体内实验可用，细胞实验请谨慎选择！
靶点
Cdk4 [1]
(Cell-free assay)		 Cdk6 [1]
(Cell-free assay)
11 nM 16 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Palbociclib在文献中得到引用

Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling [ Drug Resist Updat, 2025, 78:101161] PubMed: 39499997
Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer [ Cell Rep Med, 2025, S2666-3791(25)00231-9] PubMed: 40449480
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies [ Cell Rep Med, 2025, 6(2):101964] PubMed: 39933527
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage [ Genes Dev, 2025, 39(9-10):582-602] PubMed: 40127955
DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair [ Cell Rep, 2025, 44(4):115452] PubMed: 40117291
Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer [ NPJ Precis Oncol, 2025, 9(1):20] PubMed: 39824957
Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [ Elife, 2025, 13RP101075] PubMed: 40272409
Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis [ Elife, 2025, 14e75393] PubMed: 39791360
Gene expression analysis in circulating tumour cells to determine resistance to CDK4/6 inhibitors plus endocrine therapy in HR + /HER2- metastatic breast cancer patients [ J Transl Med, 2025, 23(1):400] PubMed: 40186268
CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds [ Mol Oncol, 2025, 10.1002/1878-0261.13799] PubMed: 39776254

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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