Pemetrexed

目录号：S5971 批次号：S597103

化学数据

	别名	LY231514	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₀H₂₁N₅O₆
	分子量	427.41	CAS号	137281-23-3
Solubility (25°C)*	体外	DMSO	85 mg/mL (198.87 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Pemetrexed (LY231514) 是一种新型的抗叶酸和抗代谢药物，针对 thymidylate synthase (TS)、dihydrofolate reductase (DHFR) 和 glycinamide ribonucleotide formyltransferase (GARFT) 在无细胞试验中，对应的Ki值分别为1.3 nM、7.2 nM和65 nM。Pemetrexed 可诱导自噬和细胞凋亡。

靶点

Thymidylate synthase ^[1] (Cell-free assay)	DHFR ^[1] (Cell-free assay)	GARFT ^[1] (Cell-free assay)
1.3 nM(Ki)	7.2 nM(Ki)	65 nM(Ki)

参考文献

[4] Takano N, et al. Anticancer Res. 2022 Feb;42(2):709-722.

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Pemetrexed在文献中得到引用

Metabolic Hallmarks for Purine Nucleotide Biosynthesis in Small Cell Lung Carcinoma [ Mol Cancer Res, 2024, 22(1):82-93]	PubMed: 37773022
A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells [ Amino Acids, 2024, 56(1):15]	PubMed: 38351332
Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells [ Cell Death Dis, 2023, 10.1038/s41419-023-06240-x]	PubMed: 37938546
Exploring the Molecular Players behind the Potentiation of Chemotherapy Effects by Durvalumab in Lung Adenocarcinoma Cell Lines [ Pharmaceutics, 2023, 15(5)1485]	PubMed: 37242727
Exploring the Molecular Players behind the Potentiation of Chemotherapy Effects by Durvalumab in Lung Adenocarcinoma Cell Lines [ Pharmaceutics, 2023, 15(5)1485]	PubMed: 37242727
Gastrodin destabilizes survivin and overcomes pemetrexed resistance [ Cell Signal, 2023, 110:110851]	PubMed: 37586466
SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence [ Stem Cells Int, 2023, 2023:7367854]	PubMed: 37274024
Immunofluorescence-Based Assay for High-Throughput Analysis of Multidrug Resistance Markers in Non-Small Cell Lung Carcinoma Patient-Derived Cells [ Diagnostics (Basel), 2023, 13(24)3617]	PubMed: 38132201
Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncology Letters, 2023, 152]	PubMed: None
Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncol Lett, 2023, 25(4):152]	PubMed: 36936028

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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