Acyclovir (Aciclovir)
别名: Acycloguanosine, ACV, NSC 645011,BW 248U 中文名称：阿昔洛韦
Acyclovir (Aciclovir)是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。
Acyclovir (Aciclovir) Chemical Structure
CAS: 59277-89-3
产品质控
批次：
纯度：
99.93%
99.93
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细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| african green monkey Vero cells | Function assay | 48 h | Antiviral activity against HSV2 strain 333 infected in african green monkey Vero cells assessed as inhibition of cytopathic effect after 48 hrs by plaque reduction assay, EC50=1.87 μM | 22704890 | |
| HEL cells | Function assay | 4 days | Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days, EC50=0.2 μM | 22459876 | |
| African green monkey Vero 76 cells | Cytotoxicity assay | 48-96 h | Cytotoxicity against African green monkey Vero 76 cells assessed as cell viability after 48 to 96 hrs by crystal violet staining, CC50=13 μM | 26119992 | |
| BSC-1 cells | Function assay | Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=2.6 μM | 2913300 | ||
| P3HR-1 cells | Function assay | Effective concentration for the inhibition of Epstein-Barr virus EBV-DNA synthesis in human lymphoblastoid P3HR-1 cells, EC50=6.75 μM | 12408726 | ||
| HFF cells | Function assay | Concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells, EC50=1.1 μM | 14584954 | ||
| HFF cells | Function assay | Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells, EC50=2.22 μM | 14584954 | ||
| human embryonic lung cells | Function assay | Antiviral activity was measured as effective concentration required to reduce Varicella Zoster virus (OKA)-induced plaque formation in human embryonic lung cells, EC50=1.1 μM | 11549457 | ||
| HEL cells | Function assay | Compound was tested for anti-viral activity against HSV-1(G) in HEL cells, EC50=1.3 μM | 14643328 | ||
| HEL cell | Function assay | Effective concentration required to inhibit Tyrosine kinase (TK+) Varicella-Zoster virus-induced cytopathicity by 50% in OKA strain HEL cell lines, EC50=4.53 μM | 11495586 | ||
| HSV-2 MS Vero cells | Function assay | Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell monolayers of HSV-2 MS Vero cells by 50%, EC50=6.2 μM | 11585457 | ||
| HSV-1 E-377 Vero cells | Function assay | Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%, EC50=4.4 μM | 11585457 | ||
| HSV-1 KOS Vero cells | Function assay | Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50%, EC50=2.2 μM | 11585457 | ||
| HeLa cell | Function assay | Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (G) in HeLa cell culture, IC50=0.19 μM | 11356110 | ||
| HEp-2 cells | Function assay | Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (K979) in HEp-2 cells | 2842506 | ||
| HeLa cells | Function assay | Inhibition of HSV-1 DNA synthesis in virus-infected HeLa cells, IC50=1.9 μM | 7752206 | ||
| human HFF cells | Function assay | Inhibitory concentration of the drug against the cytopathic effect for E-377 strain of herpes simplex virus-1 (HSV-1) in human HFF cells, EC50=0.04 μM | 8394933 | ||
| human HFF cells | Function assay | Inhibitory concentration of the drug against the cytopathic effect for MS strain of herpes simplex virus-2 (HSV-2) in human HFF cells, EC50=0.09 μM | 8394933 | ||
| MRC-5 cells | Function assay | Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 2 (HSV-2) in MRC-5 cells, IC50=2.5 μM | 2153202 | ||
| human lung fibroblasts (MRC-5) | Function assay | Compound was tested for antiviral activity against Herpes Simplex virus Type-1(18189) in human lung fibroblasts (MRC-5) | 3040998 | ||
| Raji cells | Function assay | Inhibitory concentration of the drug against the antigen production against P3HR-1 strain of epstein barr virus-2 (EBV) in Raji cells, EC50=2.9 μM | 8394933 | ||
| Vero cells | Function assay | Inhibitory activity against herpes simplex virus type 2 (HSV 2) strain 186 in Vero cells, IC50=1.7 μM | 8576922 | ||
| BSC-1 cells | Function assay | Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA, EC50=1.5 μM | 15634003 | ||
| HFF cells | Function assay | Effective concentration required to inhibit varicella zoster virus replication in HFF cells, EC50=1.6 μM | 15634003 | ||
| HFF cells | Function assay | Effective concentration required to inhibit herpes simplex virus 1 in HFF cells in cytopathic effect (CPE) assay, EC50=0.9 μM | 15634003 | ||
| Daudi cells | Function assay | Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA, EC50=0.33 μM | 17004726 | ||
| WI-38 cell | Function assay | Anti viral activity against VZV(pplla strain) in WI-38 cell monolayers, ID50=4 μM | 1316966 | ||
| HEL cells | Function assay | Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.14 μM | 23099097 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Acyclovir (Aciclovir)是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。 | |
|---|---|---|
| 靶点 |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06228430 | Not yet recruiting | Healthy Volunteer |
International Bio service |
February 12 2024 | Phase 1 |
| NCT05589688 | Not yet recruiting | Obesity |
University Hospital Toulouse |
January 2024 | Phase 1 |
| NCT06058858 | Not yet recruiting | Cytomegalovirus Infections|Acute Leukemia|B Cell Lymphoma |
Assistance Publique - Hôpitaux de Paris |
October 1 2023 | -- |
| NCT05468619 | Recruiting | Herpes Simplex |
National Institute of Allergy and Infectious Diseases (NIAID) |
September 23 2022 | Phase 1 |
化学信息&溶解度
| 分子量 | 225.2 | 分子式 | C8H11N5O3 |
| CAS号 | 59277-89-3 | SDF | Download Acyclovir (Aciclovir) SDF |
| Smiles | C1=NC2=C(N1COCCO)N=C(NC2=O)N | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 45 mg/mL ( (199.82 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : Insoluble Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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