| S2865 |
VUF 10166 |
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
Selective |
5-HT3A, Ki: 0.04 nM; 5-HT3AB, Ki: 22 nM |
| S2106 |
Azasetron HCl |
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
Selective |
5-HT3, IC50: 0.33 nM |
| S1345 |
Granisetron HCl |
Granisetron HCl is a serotonin 5-HT3 receptor antagonist. |
Selective |
|
| S1898 |
Tropisetron HCl |
Tropisetron HCl is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. |
Selective |
|
| S3050 |
Palonosetron HCl |
Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
Selective |
|
| S1390 |
Ondansetron HCl |
Ondansetron HCl is a serotonin 5-HT3 receptor antagonist. |
Selective |
|
| S1996 |
Ondansetron |
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
Selective |
|
| S2875 |
Prucalopride |
Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. |
Pan |
5-HT3, Ki: 3.822 μM |
| S2691 |
BMY 7378 |
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
Pan |
5-HT3, pIC50: <5.0 |
