| S8051 |
Macitentan |
Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM. |
Selective |
ET-A, IC50: 0.5 nM |
| S3051 |
Bosentan Hydrate |
Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
Selective |
ET-A, Ki: 4.7 nM |
| S1456 |
Zibotentan (ZD4054) |
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. |
Selective |
ET-A, IC50: 21 nM |
| S2097 |
Ambrisentan |
Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH). |
Selective |
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