| S2919 |
IOX2 |
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
Selective |
PHD2, IC50: 21 nM |
| S7309 |
BAY 87-2243 |
BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Phase 1.
|
Selective |
|
| S7612 |
PX-478 2HCl |
PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. Phase 1.
|
Selective |
|
| S1233 |
2-Methoxyestradiol (2-MeOE2) |
2-Methoxyestradiol (2-MeOE2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. |
Pan |
|
