| S1545 |
SB408124 |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
Selective |
OX1 (membrane), Ki: 27 nM; OX1 (whole cell), Ki: 57 nM |
| S7585 |
SB-334867 |
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
|
Selective |
|
| S2160 |
Almorexant HCl |
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3. |
Pan |
OX1 receptor, IC50: 6.6 nM |
