8-Bromo-cAMP

目录号：S7857 批次号：S785707

打印

化学数据

别名

8-Br-Camp,8-Bromo-cAMP Sodium

储存条件
(自收到货起)

3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂

化学式

C₁₀H₁₀BrN₅NaO₆P

分子量

430.08

CAS号

76939-46-3

Solubility (25°C)*

体外

DMSO

125 mg/mL (290.64 mM)

Water

100 mg/mL (232.51 mM)

Ethanol

Insoluble

体内（现配现用）

澄清溶液

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

4.3mg/ml (10.00mM)

以 1 mL 工作液为例，取50μL86mg/ml的澄清DMSO储备液加到400μL PEG300中，混合均匀使其澄清；向上述体系中加入50μLTween80，混合均匀使其澄清；然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

8-bromo-cAMP (8-Br-Camp)是一种细胞渗透性环AMP(cAMP)类似物，激活cAMP依赖的蛋白激酶的Ka值为0.05 μM。是一种PKA激活剂。

靶点

PKA ^[1]

0.05 μM(Ka)

体外研究

8-Bromo-cAMP提高人新生包皮纤维原(HFF1)细胞的重编程效率。^[1]

在支气管上皮细胞中，8-Bromo-cAMP减少HDE刺激的肿瘤坏死因子(TNF)-α-转化酶(TACE；ADAM-17)活性和随后的TNF-α释放。^[2]

参考文献

客户使用selleck产品的实验数据

: , Development, 2016, 143(12):2103-10.

: 数据来源于[Data independently produced by , , J Cell Mol Med, 2018, 22(11):5518-5532]

8-Bromo-cAMP在文献中得到引用

Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs [ Elife, 2024, 13RP97507]	PubMed: 39642055
MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury [ Stem Cell Res Ther, 2024, 15(1):438]	PubMed: 39563422
AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission [ Biomed Pharmacother, 2024, 176:116858]	PubMed: 38850669
Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage [ J Transl Med, 2024, 22(1):478]	PubMed: 38769534
β3-Adrenoceptor as a new player in the sympathetic regulation of the renal acid-base homeostasis [ Front Physiol, 2024, 15:1304375]	PubMed: 38455846
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm [ Protein Cell, 2023, 14(4):262-278]	PubMed: 37084236
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99]	PubMed: 37891533
METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility [ Reprod Biol Endocrinol, 2023, 21(1):99]	PubMed: 37891533
High extracellular glucose promotes cell motility by modulating cell deformability and contractility via the cAMP-RhoA-ROCK axis in human breast cancer cells [ Mol Biol Cell, 2023, 34(8):ar79]	PubMed: 37195739
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential [ Cell Res, 2022, 10.1038/s41422-022-00668-0]	PubMed: 35508506

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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