Quinidine

目录号：S2571 批次号：S257102

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化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C20H24N2O2
分子量 324.42 CAS号 56-54-2
Solubility (25°C)* 体外 DMSO 65 mg/mL (200.35 mM)
Ethanol 21 mg/mL (64.73 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent in the heart. Quinidine is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. Quinidine is used to treat abnormal heart rhythms. Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current. At micromolar concentrations, quinidine inhibits Na+/K+-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain. Quinidine is also used to treat malaria. The half life of oral quinidine is 6 to 8 hours, and it is eliminated by the cytochrome P450 system in the liver. About 20% is excreted unchanged via the kidneys. Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants. Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have CNS side effects such as respiratory depression if the two drugs are co-administered. [1][2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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