ABCG1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	ABCG1 Rabbit Recombinant mAb detects endogenous level of total ABCG1.
背景	Members of the ATP-binding cassette (ABC) transporter superfamily are involved in a wide variety of transport processes with substrates ranging from small ions to relatively large polypeptides and polysaccharides. The G subfamily of ABC transporters consists of half-transporters, which oligomerise to form the functional transporter. While ABCG1, ABCG4 and ABCG5/8 are involved in the ATPdependent translocation of steroids and, possibly, other lipids, ABCG2 has been identified as a multidrug transporter that confers resistance on tumor cells. ABCG1 is the first member of the ABCG subfamily. The protein is expressed in the plasma membrane of adipocytes, macrophages, and other cell types. In these cells, ABCG1 is thought to redistribute cholesterol to a cellsurface pool that is accessible to enzymatic oxidation and to removal by high-density lipoprotein (HDL) particles. ABCG1 has also been linked to atherosclerosis as the protein prevents excessive uptake of cholesterol in macrophages, which can lead to foam cell formation.

特异性

ABCG1 Rabbit Recombinant mAb detects endogenous level of total ABCG1.

背景

Members of the ATP-binding cassette (ABC) transporter superfamily are involved in a wide variety of transport processes with substrates ranging from small ions to relatively large polypeptides and polysaccharides. The G subfamily of ABC transporters consists of half-transporters, which oligomerise to form the functional transporter. While ABCG1, ABCG4 and ABCG5/8 are involved in the ATPdependent translocation of steroids and, possibly, other lipids, ABCG2 has been identified as a multidrug transporter that confers resistance on tumor cells. ABCG1 is the first member of the ABCG subfamily. The protein is expressed in the plasma membrane of adipocytes, macrophages, and other cell types. In these cells, ABCG1 is thought to redistribute cholesterol to a cellsurface pool that is accessible to enzymatic oxidation and to removal by high-density lipoprotein (HDL) particles. ABCG1 has also been linked to atherosclerosis as the protein prevents excessive uptake of cholesterol in macrophages, which can lead to foam cell formation.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Rat

MW (kDa)

110kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Velamakanni S, et al. J Bioenerg Biomembr. 2007, 39(5-6):465-71.

Application Data

WB

Validated by Selleck