ADORA1 Rabbit Recombinant mAb

生物描述

特异性

ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1.

背景

The protective response to neuron damage is mainly due to endogenous adenosine. Adenosine P1 receptors are a class of purinergic and G protein-coupled receptors using adenosine as a ligand and consist of A1, A2a, A2b, and A3 subtypes. All adenosine receptors have been shown to activate at least one subfamily of mitogen-activated protein kinases. ADORA1 activation inhibits the release of presynaptic transmitters and stabilizes the postsynaptic membrane potential to reduce neuronal transmission and excitability. ADORA2A, another high affinity receptor, is thought to be preferentially activated by a high frequency stimulus, and then strengthen selected synaptic transmission within a globally inhibited network that could be formed by ADORA1 activation. ADORA1 is also an E2/ERα target and a regulator of ERα transcriptional activity.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	37kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Huang J, et al. Neurochem Res. 2016, 41(7):1774-83. [2] Lin Z, et al. Oncogene. 2010, 29(8):1114-22.

Application Data

WB

IHC