AF488 EGF Receptor Antibody [K22M8]

目录号:H4209

打印

生物描述

特异性
背景 表皮生长因子(EGF)受体是一种跨膜酪氨酸激酶,属于HER/ErbB蛋白家族。配体结合导致受体二聚化、自磷酸化、下游信号激活、内化和溶酶体降解。EGF受体(EGFR)在激酶结构域的Tyr845处的磷酸化与稳定激活环、维持酶的活性状态以及为底物蛋白提供结合表面有关。c-Src参与EGFR在Tyr845处的磷酸化。PLCγ的SH2结构域结合在磷酸化Tyr992处,导致PLCγ介导的下游信号激活。

使用信息

抗体应用 FCM, IHC, IF 推荐用量 5 uL/million cells in 100 µL volume
反应性 Human, Mouse, Monkey
抗体类型 Rabbit MW 175 kDa
储存液配方 Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA
储存条件
(自收到货起)
Store at 4°C in the dark to avoid freeze-thaw cycles

Application Data

FCM

Validated by Selleck

  • Staining phosphorylated/permeabilized Jurkat cells with AF488 EGF Receptor Antibody (Clone: K22M8) (Product Number: H4209) (green, red is unstained control). Analysis was performed on total cells.