Caspr Rabbit Recombinant mAb Datasheet

生物描述

特异性	Caspr Rabbit Recombinant mAb detects endogenous level of total Caspr.
背景	Specialized paranodal junctions form between the axon and the closely apposed paranodal loops of myelinating glia. They are interposed between sodium channels at the nodes of Ranvier and potassium channels in the juxtaparanodal regions. Caspr (contactin-associated protein, also termed paranodin) is a major axonal constituent of these junctions. It is expressed diffusely on unmyelinated axons but becomes localized to the paranodal junctions shortly after the onset of myelination. The contactin-associated protein (Caspr) family, primarily comprising Caspr1-5, participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons.

特异性

Caspr Rabbit Recombinant mAb detects endogenous level of total Caspr.

背景

Specialized paranodal junctions form between the axon and the closely apposed paranodal loops of myelinating glia. They are interposed between sodium channels at the nodes of Ranvier and potassium channels in the juxtaparanodal regions. Caspr (contactin-associated protein, also termed paranodin) is a major axonal constituent of these junctions. It is expressed diffusely on unmyelinated axons but becomes localized to the paranodal junctions shortly after the onset of myelination. The contactin-associated protein (Caspr) family, primarily comprising Caspr1-5, participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

165kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Rios JC, et al. J Neurosci. 2000, 20(22):8354-64.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck