Colchicine

目录号：S2284 批次号：S228407

化学数据

	别名	Colchineos, Colchisol, Colcin,NSC 757	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₂H₂₅NO₆
	分子量	399.44	CAS号	64-86-8
Solubility (25°C)*	体外	DMSO	80 mg/mL (200.28 mM)
		Water	80 mg/mL (200.28 mM)
		Ethanol	80 mg/mL (200.28 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Colchicine是一种微管聚合抑制剂， IC50为3 nM。

参考文献

[1] Niu L, et al. J Biol Chem. 2019 Nov 29;294(48):18099-18108.

Colchicine在文献中得到引用

Dual inhibition of topoisomerase II and microtubule of podophyllotoxin derivative 5p overcomes cancer multidrug resistance [ Eur J Pharmacol, 2024, 983:176968]	PubMed: 39233039
Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma [ Biomedicines, 2024, 12(2)406]	PubMed: 38398008
Endothelial cell elongation and alignment in response to shear stress requires acetylation of microtubules [ Front Physiol, 2024, 15:1425620]	PubMed: 39318362
MI-181 Modulates Cilia Length and Restores Cilia Length in Cells with Defective Shortened Cilia [ ACS Chem Biol, 2024, 19(8):1733-1742]	PubMed: 39106364
Restricting epigenetic activity promotes the reprogramming of transformed cells to pluripotency in a line-specific manner [ Cell Death Discov, 2023, 9(1):245]	PubMed: 37452056
DNA nicks induce mutational signatures associated with BRCA1 deficiency [ Nat Commun, 2022, 13(1):4285]	PubMed: 35879372
DNA nicks induce mutational signatures associated with BRCA1 deficiency [ Nat Commun, 2022, 13(1):4285]	PubMed: 35879372
Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment [ Transl Stroke Res, 2022, 10.1007/s12975-022-01022-7]	PubMed: 35441983
Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2-Mediated Suppression of NLRP3 Inflammasome Activation [ J Am Heart Assoc, 2022, 11(13):e025266]	PubMed: 35766262
IMB5476, a novel microtubule inhibitor, induces mitotic catastrophe and overcomes multidrug resistance in tumors [ Eur J Pharmacol, 2022, 919:174802]	PubMed: 35143830

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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