Cycloheximide

目录号：S7418 批次号：S741805

化学数据

	别名	NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80	储存条件 (自收到货起)	3年 -20°C(避光) 粉状
	化学式	C₁₅H₂₃NO₄
	分子量	281.35	CAS号	66-81-9
Solubility (25°C)*	体外	DMSO	56 mg/mL (199.04 mM)
		Ethanol	56 mg/mL (199.04 mM)
		Water	15 mg/mL (53.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80)，一种抗真菌抗生素，是一种真核生物蛋白质合成（protein synthesis）抑制剂，对体内蛋白质合（protein synthesis）和 RNA 合成（RNA synthesis）的 IC50 分别为 532.5 nM 和 2880 nM。Cycloheximide抑制铁死亡并抑制自噬。在溶液中不稳定，请现配现用！此产品为危化品（急性毒性/易燃/皮肤腐蚀），请在穿戴防护面罩、防护手套和防护服后使用。

参考文献

[4] Santos DA, et al. Nucleic Acids Res. 2019;47(10):4974-4985.

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Cycloheximide在文献中得到引用

Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer [ Signal Transduct Target Ther, 2024, 9(1):65]	PubMed: 38461173
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway [ Mol Cancer, 2024, 23(1):143]	PubMed: 38992675
Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis [ Cell Metab, 2024, 36(7):1598-1618.e11]	PubMed: 38772364
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation [ J Hematol Oncol, 2024, 17(1):77]	PubMed: 39218923
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma [ J Hematol Oncol, 2024, 17(1):78]	PubMed: 39218945
Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers [ Bioact Mater, 2024, 32:277-291]	PubMed: 37876556
Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors [ Nat Commun, 2024, 15(1):5209]	PubMed: 38890388
Wild-type IDH2 is a therapeutic target for triple-negative breast cancer [ Nat Commun, 2024, 15(1):3445]	PubMed: 38658533
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death [ Nat Commun, 2024, 15(1):1282]	PubMed: 38346956
Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation [ Cancer Commun (Lond), 2024, 10.1002/cac2.12595]	PubMed: 39030964

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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