Deferoxamine mesylate

目录号：S5742 批次号：S574209

化学数据

	别名	Ba 33112, Desferrioxamine B, DFOM, NSC 644468, DFO	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₆H₅₂N₆O₁₁S
	分子量	656.79	CAS号	138-14-7
Solubility (25°C)*	体外	Water	100 mg/mL (152.25 mM)
		DMSO	50 mg/mL (76.12 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Deferoxamine mesylate是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。请不要用生理盐水或者PBS配制储存液，可能会产生沉淀。

靶点

HIF-1α ^[1]

Beta Amyloid ^[1]

Ferroptosis ^[2]

参考文献

[4] Sanan S, et al. Resuscitation. 1989 Feb;17(1):63-75.

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Deferoxamine mesylate在文献中得到引用

Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction [ Cancer Commun (Lond), 2024, 10.1002/cac2.12608]	PubMed: 39221971
Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development [ Cell Rep Med, 2024, 5(3):101476]	PubMed: 38508138
Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis [ Emerg Microbes Infect, 2024, 13(1):2382235]	PubMed: 39017655
Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R [ Redox Biol, 2024, 72:103154]	PubMed: 38626575
Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis [ Redox Biol, 2024, 69:103008]	PubMed: 38142586
The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis [ Cell Death Dis, 2024, 15(8):600]	PubMed: 39160159
Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma [ J Transl Med, 2024, 22(1):593]	PubMed: 38918793
Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron [ Antioxidants (Basel), 2024, 13(9)1095]	PubMed: 39334754
Silica nanoparticles induce ferroptosis of HUVECs by triggering NCOA4-mediated ferritinophagy [ Ecotoxicol Environ Saf, 2024, 270:115889]	PubMed: 38150751
Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells [ J Virol, 2024, 98(3):e0189723]	PubMed: 38411946

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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