生物描述

特异性

ERp57 Rabbit Recombinant mAb detects endogenous levels of total ERp57.

背景

The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum to be involved in the proper folding and quality control of glycoproteins, and participates in the assembly of the major histocompatibility complex class 1. ERp57 is also present in many other subcellular locations and implicated in a variety of functions such as the participation in signal transduction from the cell surface, regulatory processes taking place in the nucleus, and multimeric protein complexes involved in DNA repair. In mitochondria, ERp57 associates with a mitochondrial calpain and appears to stabilize calpain, opposing its degradation by other mitochondrial proteases. It may be involved in a process leading to apoptosis.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	57kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Turano C, et al. Cell Mol Biol Lett. 2011, 16(4):539-63.

Application Data

WB

IHC