Fer-1 (Ferrostatin-1)

目录号：S7243 批次号：S724304

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₁₅H₂₂N₂O₂
	分子量	262.35	CAS号	347174-05-4
Solubility (25°C)*	体外	DMSO	52 mg/mL (198.2 mM)
		Ethanol	52 mg/mL (198.2 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Fer-1 (Ferrostatin-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。

靶点

Ferroptosis ^[1]
(HT-1080 cells)

60 nM(EC50)

体外研究

Ferrostatin-1(2 μM)作用于癌细胞，抑制Erastin诱导的Ferroptosis，Ferroptosis是一种铁依赖性的的非凋亡性细胞死亡，Ferrostatin-1作用于新生大鼠脑片，抑制谷氨酸盐诱导的细胞死亡。Ferrostatin-1是一种脂质ROS清除剂，具有N-环己基部分，作为生物膜内亲脂锚。Ferrostatin-1不抑制细胞外信号调节激酶（ERK）磷酸化或HT-1080细胞增殖停滞，说明Ferrostatin-1不抑制MEK/ERK通路，螯合铁，或抑制蛋白合成。Ferrostatin-1抑制Erastin诱导的胞浆和脂质ROS积累。无细胞条件下，Ferrostatin-1容易氧化稳定自由基2,2-二苯基-1-苦肼基（DPPH）。^[1]

参考文献

客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by , , Hepatology, 2016, 64(2):488-500]

: 数据来源于[Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]

: 数据来源于[Data independently produced by , , Oncogene, 2015, 10.1038/onc.2015.32]

: 数据来源于[Data independently produced by , , Mol Carcinog, 2018, 57(11):1566-1576]

Fer-1 (Ferrostatin-1)在文献中得到引用

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism [ Nat Commun, 2025, 16(1):509]	PubMed: 39779666
Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis [ Cell Rep Med, 2025, 6(2):101928]	PubMed: 39879992
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma [ Biomaterials, 2025, 319:123168]	PubMed: 40015005
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation [ EMBO J, 2025, 10.1038/s44318-025-00369-5]	PubMed: 39881208
ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 [ Biomark Res, 2025, 13(1):17]	PubMed: 39849645
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway [ J Adv Res, 2025, S2090-1232(25)00058-X]	PubMed: 39870301
LncRNA CRCMSL interferes in phospholipid unsaturation to suppress colorectal cancer progression via reducing membrane fluidity [ J Adv Res, 2025, S2090-1232(25)00075-X]	PubMed: 39921055
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells [ Cell Death Dis, 2025, 16(1):28]	PubMed: 39827156
Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment [ Cell Death Dis, 2025, 16(1):42]	PubMed: 39863613
Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism [ Br J Cancer, 2025, 132(4):384-400]	PubMed: 39706989

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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