IBMX

目录号：S5836 批次号：S583604

化学数据

	别名	Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₀H₁₄N₄O₂
	分子量	222.24	CAS号	28822-58-4
Solubility (25°C)*	体外	DMSO	45 mg/mL (202.48 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine)是一种非特异性phosphodiesterase (PDE)抑制剂，对PDE3、PDE4、PDE5的IC50值分别为6.5±1.2, 26.3±3.9 和 31.7±5.3 μM。它能增强细胞内cAMP水平，是adenosine (A1) receptor拮抗剂。

靶点

PDE3 ^[1]	PDE4 ^[1]	PDE5 ^[1]
6.5 μM	26.3 μM	31.7 μM

参考文献

[4] Hosseini A, et al. Iran J Basic Med Sci. 2012;15(4):916-925.

+ 展开

IBMX在文献中得到引用

LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia [ J Hematol Oncol, 2023, 16(1):30]	PubMed: 36973755
LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia [ J Hematol Oncol, 2023, 16(1):30]	PubMed: 36973755
Kinase-Modulated Bioluminescent Indicators Enable Noninvasive Imaging of Drug Activity in the Brain [ ACS Cent Sci, 2023, 9(4):719-732]	PubMed: 37122464
Kinase-Modulated Bioluminescent Indicators Enable Noninvasive Imaging of Drug Activity in the Brain [ ACS Cent Sci, 2023, 9(4):719-732]	PubMed: 37122464
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion [ Phytomedicine, 2023, 118:154942]	PubMed: 37421767
PTHrP Modulates the Proliferation and Osteogenic Differentiation of Craniofacial Fibrous Dysplasia-Derived BMSCs [ Int J Mol Sci, 2023, 24(8)7616]	PubMed: 37108778
Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation [ Nat Commun, 2022, 13(1):3419]	PubMed: 35701426
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis [ Bone Res, 2022, 10(1):27]	PubMed: 35260562
Rapid recovery of male cats with postrenal acute kidney injury by treating with allogeneic adipose mesenchymal stem cell-derived extracellular vesicles [ Stem Cell Res Ther, 2022, 13(1):379]	PubMed: 35902973
Rapamycin improves the quality and developmental competence of in vitro matured oocytes in aged mice and humans [ Aging (Albany NY), 2022, 14(22):9200-9209]	PubMed: 36441531

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。