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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
化学式 | C13H11BrN2O3 |
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分子量 | 323.14 | CAS号 | 2093387-36-9 | |
Solubility (25°C)* | 体外 | DMSO | 21 mg/mL (64.98 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Lenalidomide-Br是lenalidomide的溴化类似物,旨在用作PROTAC研究中的化学工具。它作为cereblon (CRBN)的募集配体,通过CRL4CRBN E3泛素连接酶复合物实现靶向蛋白质降解。 |
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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma [ Nat Commun, 2022, 13(1):1009] | PubMed: 35197447 |
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma [ Cell Death Dis, 2022, 13(3):197] | PubMed: 35236820 |
SORT1/LAMP2-mediated Extracellular Vesicle Secretion and Cell Adhesion Are Linked to Lenalidomide Resistance in Multiple Myeloma [ Blood Adv, 2022, bloodadvances.2021005772] | PubMed: 34979567 |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma [ Nat Commun, 2021, 12(1):5183] | PubMed: 34465776 |
Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation [ Blood Cancer J, 2021, 11(12):194] | PubMed: 34864816 |
IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK [ Leukemia, 2021, 35(5):1330-1343] | PubMed: 33623139 |
Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma [ Blood Adv, 2021, 5(9):2391-2402] | PubMed: 33950175 |
IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform [ Cell Death Discov, 2021, 7(1):139] | PubMed: 34117218 |
Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells [ Hemasphere, 2021, 5(7):e602] | PubMed: 34136753 |
Fractionated Irradiation of Right Thorax Induces Abscopal Damage on Bone Marrow Cells via TNF-α and SAA [ Int J Mol Sci, 2021, 22(18)9964] | PubMed: 34576128 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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