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别名 | APDC, Pyrrolidine dithiocarbamic acid ammonium salt | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
化学式 | C5H9NS2.H3N |
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分子量 | 164.29 | CAS号 | 5108-96-3 | |
Solubility (25°C)* | 体外 | DMSO | 32 mg/mL (194.77 mM) | |
Water | 32 mg/mL (194.77 mM) | |||
Ethanol | 3 mg/mL (18.26 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | PDTC (Pyrrolidinedithiocarbamate ammonium)是NF-κB的有效抑制剂,抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。 | |
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靶点 |
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Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532] | PubMed: 38727248 |
Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway [ Gut Microbes, 2024, 16(1):2351532] | PubMed: 38727248 |
Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte [ Cell Death Discov, 2024, 10(1):381] | PubMed: 39187478 |
Trim72 is a major host factor protecting against lethal Candida albicans infection [ PLoS Pathog, 2024, 20(11):e1012747] | PubMed: 39585917 |
Anti-tumor effects of telmisartan in glioma-astrocyte non-contact co-cultures: A critical role of astrocytic IL-6-mediated paracrine growth promotion [ Int Immunopharmacol, 2024, 139:112707] | PubMed: 39032472 |
The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF-κB/MMP9 [ CNS Neurosci Ther, 2024, 30(12):e70130] | PubMed: 39648661 |
Helicobacter pylori with trx1 high expression promotes gastric diseases via upregulating the IL23A/NF-κB/IL8 pathway [ Helicobacter, 2024, 29(2):e13072] | PubMed: 38686467 |
Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity [ J Cancer Res Clin Oncol, 2024, 150(3):159] | PubMed: 38530432 |
A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors [ Sci Adv, 2024, 10(34):eadl3975] | PubMed: 39167656 |
Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling [ Mol Metab, 2023, 75:101766] | PubMed: 37406987 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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