Recombinant Mouse IL-5 Protein, BSA (HEK293)

目录号:C0014

打印

Recombinant Mouse IL-5 Protein is expressed from HEK293 with His tag at the C-terminus. It contains Met21-Gly133.

生物描述

Accession
P04401-1
别名
IL-5, TRF, IL5, Interleukin-5
背景
白介素 5 (IL5) 是由 2 型 T 辅助细胞和肥大细胞产生的白介素。IL-5 是一种长 115 个氨基酸(在人类中为 115 个氨基酸,在小鼠中为 133 个氨基酸)的 TH2 细胞因子,属于造血细胞因子家族。与该细胞因子家族的其他成员(即白介素 3 和 GM-CSF)不同,这种糖蛋白的活性形式为同型二聚体。长期以来,白介素 5 一直与多种过敏性疾病的病因相关,包括过敏性鼻炎和哮喘,这些疾病中已观察到循环、气道组织和诱导痰中嗜酸性粒细胞数量大幅增加。鉴于嗜酸性粒细胞(尤其是过敏性哮喘病理)的高度一致性,人们普遍推测嗜酸性粒细胞在该疾病的病理学中起着重要作用。靶向 IL-5 的药物有美泊利单抗和瑞利珠单抗。
参考文献

使用信息

物种
Mouse
标签
His tag at the N-terminus.
来源
HEK293-drived mouse IL-6 protein Met21-Gly133.
预测分子量
13.1 kDa
实际分子量
15-21 kDa, reducing conditions
纯度
>95% as determined by Bis-Tris PAGE.
内毒素
< 0.1 EU/ug by the LAL method
制剂
Lyophilized from 0.22μm filtered solution in PBS with BSA as a carrier protein. Normally 8% trehalose is added as protectant before lyophilization.
储存条件 (自收到货起)
Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data

Quality Inspection Chart of Recombinant Mouse IL-5 Protein, BSA (HEK293)