Recombinant Mouse IL-6 Protein, BSA (HEK293)

目录号：C0016

打印

Recombinant Mouse IL-6 Protein is expressed from HEK293 with His tag at the N-terminus. It contains Phe25-Thr211.

生物描述

Accession

P08505-1

别名

IFN-beta-2; IL6; IL-6; BSF-2; CDF; MGI-2A; Interleukin-6; HSF; IFNB2; HGF;IFN-β-2

背景

白细胞介素 6 (IL-6) 也称为 HGF、BSF2、HSF、IFNB2 和 IL-6，最初被鉴定为 B 细胞分化因子，是一种多功能细胞因子，可调节免疫反应、造血、急性期反应和炎症反应。它由 T 细胞、巨噬细胞、单核细胞、成纤维细胞、内皮细胞等分泌，以刺激对创伤（尤其是烧伤或其他导致炎症的组织损伤）的免疫反应。白细胞介素 6 已被证明与白细胞介素 6 受体和糖蛋白相互作用。IL-6 与许多疾病过程有关，例如糖尿病、动脉粥样硬化、抑郁症、阿尔茨海默病、系统性红斑狼疮、前列腺癌和类风湿性关节炎。晚期/转移性癌症患者血液中的 IL-6 水平较高。因此，开发抗 IL-6 药物作为治疗此类疾病的药物具有很大前景。

参考文献

使用信息

物种

Mouse

标签

His tag at the N-terminus.

来源

HEK293-drived mouse IL-6 protein Phe25-Thr211.

活性

Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.69 ng/mL.

预测分子量

23.6 kDa

实际分子量

25-30 kDa, reducing conditions

纯度

>95% as determined by Bis-Tris PAGE.

内毒素

< 0.1 EU/ug by the LAL method

制剂

Lyophilized from 0.22μm filtered solution in PBS with BSA as a carrier protein. Normally 8% trehalose is added as protectant before lyophilization.

储存条件 (自收到货起)

Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data