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别名 | RU320521 | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C19H12Cl2N4O3 |
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分子量 | 415.23 | CAS号 | 2262452-06-0 | |
Solubility (25°C)* | 体外 | DMSO | 83 mg/mL (199.88 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | RU.521 (RU320521)是一种活跃的 cyclic GMP-AMP synthase (cGAS) 的有效的选择性抑制剂,可抑制cGAS介导的信号传导,其IC50值为700 nM。RU.521 与cGAS/dsDNA 复合物结合的Kd值为36.2 nM。 | ||||
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靶点 |
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Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] | PubMed: 38325769 |
Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway [ Virus Res, 2024, 343:199344] | PubMed: 38431054 |
Luteolin inhibits herpes simplex virus 1 infection by activating cyclic guanosine monophosphate-adenosine monophosphate synthase-mediated antiviral innate immunity [ Phytomedicine, 2023, 120:155020] | PubMed: 37632997 |
Spinal TAOK2 contributes to neuropathic pain via cGAS-STING activation in rats [ iScience, 2023, 26(10):107792] | PubMed: 37720090 |
Spinal TAOK2 contributes to neuropathic pain via cGAS-STING activation in rats [ iScience, 2023, 26(10):107792] | PubMed: 37720090 |
FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy [ Proc Natl Acad Sci U S A, 2022, 119(43):e2208506119] | PubMed: 36256824 |
AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma [ Cancers (Basel), 2022, 14(3)572] | PubMed: 35158840 |
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy [ Mol Neurobiol, 2022, 59(11):7006-7024] | PubMed: 36070120 |
Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats [ J Inflamm Res, 2022, 15:5103-5119] | PubMed: 36091334 |
Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response [ Cell Mol Life Sci, 2021, 10.1007/s00018-021-03902-x] | PubMed: 34308492 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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