生物描述

特异性

SDHB Rabbit Recombinant mAb detects endogenous levels of total SDHB.

背景

Succinate dehydrogenase (SDH)/mitochondrial complex II is a key respiratory enzyme located in the inner mitochondrial membrane that links the Krebs tricarboxylic acid cycle to oxidative phosphorylation. The SDH complex comprises of 5 proteins (SDHA, SDHB, SDHC, SDHD and SDHAF2). Loss of SDHB expression leads to a tumorigennic mechanism involving the stabilization of Hypoxia Inducing Factors (HIF), which in turn upregulates genes that promote adaptation of cells in low-oxygen environments by inducing angiogenesis and glycolysis.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	32kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Kristine M. Cornejo, et al. Hum Pathol. 2015, 46(6): 820–826. [2] Jeanny H. Wang, et al. J Cancer. 2011, 2: 90–93.

Application Data

WB

IHC