SN-011

目录号：E1066 批次号：E106603

打印

化学数据

别名

GUN35901

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₂₅H₁₉FN₂O₄S

分子量

462.49

CAS号

2249435-90-1

Solubility (25°C)*

体外

DMSO

93 mg/mL (201.08 mM)

Ethanol

6 mg/mL (12.97 mM)

Water

Insoluble

体内
（现配现用）

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

SN-011是 STING 特异性抑制剂，IC50 为 76 nM。

靶点

STING

76 nM

参考文献

[1] Ze Hong, et al. Proc Natl Acad Sci U S A . 2021 Jun 15;118(24):e2105465118.

SN-011在文献中得到引用

ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer [ Nature Communications, 2025, 10983]	PubMed: 41361170.0
Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1 [ Theranostics, 2025, 3207-3222]	PubMed: 40083918.0
Mild microwave hyperthermia promotes mitotic catastrophe, induces time-delayed cGAS-STING activation and restores sensitivity to anti-PDL1 therapy in Pan02 pancreatic cancer model [ OncoImmunology, 2025, 2602216]	PubMed: 41399970.0
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment [ Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297]	PubMed: 40032274
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment [ Molecular Pharmaceutics, 2025, 2108-2121]	PubMed: 40032274.0
YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment [ Mol Cancer, 2024, 23(1):186]	PubMed: 39237909
YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment [ Molecular Cancer, 2024, 186]	PubMed: 39237909.0

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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