STIM1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	STIM1 Rabbit Recombinant mAb detects endogenous level of total STIM1.
背景	Stromal interaction molecules (STIM) were identified as the endoplasmic-reticulum (ER) Ca2+ sensor controlling store-operated Ca2+ entry (SOCE) and Ca2+-release-activated Ca2+ (CRAC) channels in non-excitable cells. STIM1 is predominantly located in the ER, the main intracellular Ca2+ store. The ER-resident STIM1 controls Orai function by activating these channels upon ER Ca2+-store depletion. While the role of SOCE is well established in T cells and other non-excitable cells, it is becoming clear that SOCE may play a very important role in skeletal-muscle physiology, ranging from roles in development, differentiation, contractile function and resistance against fatigue. STIM1 plays a central role in these processes by controlling SOCE channels, like Orai1 and/or TRPCs in a rapid and highly regulated fashion.

特异性

STIM1 Rabbit Recombinant mAb detects endogenous level of total STIM1.

背景

Stromal interaction molecules (STIM) were identified as the endoplasmic-reticulum (ER) Ca2+ sensor controlling store-operated Ca2+ entry (SOCE) and Ca2+-release-activated Ca2+ (CRAC) channels in non-excitable cells. STIM1 is predominantly located in the ER, the main intracellular Ca2+ store. The ER-resident STIM1 controls Orai function by activating these channels upon ER Ca2+-store depletion. While the role of SOCE is well established in T cells and other non-excitable cells, it is becoming clear that SOCE may play a very important role in skeletal-muscle physiology, ranging from roles in development, differentiation, contractile function and resistance against fatigue. STIM1 plays a central role in these processes by controlling SOCE channels, like Orai1 and/or TRPCs in a rapid and highly regulated fashion.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

77kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Kiviluoto S, et al. Skelet Muscle. 2011, 1(1):16.

Application Data

WB

Validated by Selleck