T-5224

目录号：S8966 批次号：S896608

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₉H₂₇NO₈
	分子量	517.53	CAS号	530141-72-1
Solubility (25°C)*	体外	DMSO	100 mg/mL (193.22 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

T-5224 是一种转录因子 c-Fos/activator protein (AP)-1 的选择性抑制剂，并具有抗炎作用。T-5224 可特异性地抑制 c-Fos/c-Jun 的DNA结合活性和 IL-1β 诱导的 Mmp-3、Mmp-13 和 Adamts-5 转录的上调。

靶点

c-Fos/AP-1 ^[1]

c-Jun ^[1]

IL-1β ^[1]

MMP-3 ^[1]

MMP-13 ^[1]

参考文献

[1] Yukihiko Aikawa, et al. Nat Biotechnol. 2008 Jul;26(7):817-23.

T-5224在文献中得到引用

Dynamic regulation of tissue fluidity controls skin repair during wound healing [ Cell, 2024, S0092-8674(24)00825-0]	PubMed: 39168124
Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice [ Nat Commun, 2024, 15(1):10482]	PubMed: 39695111
Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging [ iScience, 2024, 27(5):109708]	PubMed: 38706856
AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance [ bioRxiv, 2024, 2024.07.25.604999]	PubMed: 39091739
Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells [ Adv Sci (Weinh), 2023, 10(25):e2301059]	PubMed: 37395651
c-FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma [ Clin Transl Med, 2023, 13(8):e1364]	PubMed: 37581569
c-FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma [ Clin Transl Med, 2023, 13(8):e1364]	PubMed: 37581569
Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice [ J Transl Med, 2023, 21(1):467]	PubMed: 37452307
Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice [ J Transl Med, 2023, 21(1):467]	PubMed: 37452307
Androgen Receptor/AP-1 Activates UGT2B15 Transcription to Promote Esophageal Squamous Cell Carcinoma Invasion [ Cancers (Basel), 2023, 15(24)5719]	PubMed: 38136265

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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