Trastuzumab deruxtecan (DS-8201a, T-DXd)

目录号：D4001         批次号: D400106

打印

Trastuzumab deruxtecan (DS-8201a, T-DXd) 是一种抗体药物偶联物 (antibody-drug conjugate，ADC)，由抗 HER2（人表皮生长因子受体 2）抗体和细胞毒性拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 显示出持久的抗肿瘤活性。Trastuzumab deruxtecan分子量为153KDa。

化学数据

CAS号 1826843-81-5
分子量 153000
配置 100 mM Pro-Ac, 20 mM Arg, pH 5.0
DAR 7.8
ADC antiody Trastuzumab
ADC cytotoxin DXd
纯度 99%
蛋白浓度 7.769mg/ml
内毒素 ＜1EU/mg

Trastuzumab deruxtecan (DS-8201a, T-DXd)在文献中得到引用

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer [ Advanced Science, 2025, 2413527] PubMed: 39950924.0
Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer [ JCI Insight, 2025, e187151] PubMed: 40857406.0
Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer [ JCI Insight, 2025, 10(16)e187151] PubMed: 40857406

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