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别名 | N/A | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |||
化学式 | C21H23ClF3N3O3 |
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分子量 | 457.87 | CAS号 | 2086257-77-2 | ||||
Solubility (25°C)* | 体外 | DMSO | 92 mg/mL (200.93 mM) | ||||
Ethanol | 92 mg/mL (200.93 mM) | ||||||
Water | Insoluble | ||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | VBIT-4 是一种 voltage-dependent anion channel (VDAC) oligomerization 的抑制剂,可降低在系统性红斑狼疮小鼠模型中 mitochondrial DNA (mtDNA) 的释放、type I interferon (IFN) 的信号传导、中性粒细胞胞外陷阱和疾病的严重性。 | ||||||
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靶点 |
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cGAS-STING drives ageing-related inflammation and neurodegeneration [ Nature, 2023, 620(7973):374-380] | PubMed: 37532932 |
Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response [ Acta Pharm Sin B, 2023, 13(12):4765-4784] | PubMed: 38045042 |
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis [ J Autoimmun, 2023, 138:103061] | PubMed: 37244073 |
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma [ Neoplasia, 2023, 44:100935] | PubMed: 37717471 |
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma [ Neoplasia, 2023, 44:100935] | PubMed: 37717471 |
[VDAC1 participates in house dust mite-induced asthmatic airway inflammation in mice by inducing ferroptosis of airway epithelial cells] [ Nan Fang Yi Ke Da Xue Xue Bao, 2023, 10.1158/0008-5472.CAN-23-0650] | PubMed: 37712269 |
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism [ Nat Commun, 2022, 13(1):7338] | PubMed: 36443305 |
Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction [ Redox Biol, 2022, 58:102519] | PubMed: 36327794 |
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase [ Free Radic Biol Med, 2022, 193(Pt 1):202-212] | PubMed: 36228830 |
Mitochondrial event as an ultimate step in ferroptosis [ Cell Death Discov, 2022, 8(1):414] | PubMed: 36209144 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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