Vincristine

目录号：S9555

化学数据

	别名	Leurocristine, NSC-67574, 22-Oxovincaleukoblastine	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₄₆H₅₆N₄O₁₀
	分子量	824.96	CAS号	57-22-7
Solubility (25°C)*	体外


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述	Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) 是长春花中的生物碱，具有抗肿瘤活性。Vincristine 可抑制有丝分裂纺锤体中的微管 microtubule 形成，其结合微管的Ki值为85 nM。

参考文献

Vincristine在文献中得到引用

Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap [ Front Pharmacol, 2024, 15:1459820]	PubMed: 39329123
Protective effect of oxytocin on vincristine-induced gastrointestinal dysmotility in mice [ Front Pharmacol, 2024, 15:1270612]	PubMed: 38655179
Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling [ Biomolecules, 2024, 14(7)741]	PubMed: 39062456
Hypoxia-initiated Cysteine-rich protein 61 secretion promotes chemoresistance of acute B lymphoblastic leukemia cells [ Am J Cancer Res, 2024, 14(7):3388-3403]	PubMed: 39113880
Panobinostat Synergizes with Chemotherapeutic Agents and Improves Efficacy of Standard-of-Care Chemotherapy Combinations in Ewing Sarcoma Cells [ Cancers (Basel), 2024, 16(21)3565]	PubMed: 39518006
Dual inhibition of topoisomerase II and microtubule of podophyllotoxin derivative 5p overcomes cancer multidrug resistance [ Eur J Pharmacol, 2024, 983:176968]	PubMed: 39233039
3-nitropyridine analogues as novel microtubule-targeting agents [ PLoS One, 2024, 19(11):e0307153]	PubMed: 39509402
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Novel iminocoumarine imidazo [4, 5-b] pyridine derivatives: Design, synthesis and biological evaluation [ Chem Heterocycl Com+, 2024, Volume 60, pages 75–82]	PubMed: None

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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