Vincristine

目录号：S9555

化学数据

	别名	Leurocristine, NSC-67574, 22-Oxovincaleukoblastine	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₄₆H₅₆N₄O₁₀
	分子量	824.96	CAS号	57-22-7
Solubility (25°C)*	体外


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) 是长春花中的生物碱，具有抗肿瘤活性。Vincristine 可抑制有丝分裂纺锤体中的微管 microtubule 形成，其结合微管的Ki值为85 nM。

参考文献

Vincristine在文献中得到引用

Overcoming drug resistance of cancer cells by targeting the FGF1/FGFR1 axis with honokiol or FGF ligand trap [ Front Pharmacol, 2024, 15:1459820]	PubMed: 39329123
Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling [ Biomolecules, 2024, 14(7)741]	PubMed: 39062456
Hypoxia-initiated Cysteine-rich protein 61 secretion promotes chemoresistance of acute B lymphoblastic leukemia cells [ Am J Cancer Res, 2024, 14(7):3388-3403]	PubMed: 39113880
3-nitropyridine analogues as novel microtubule-targeting agents [ PLoS One, 2024, 19(11):e0307153]	PubMed: 39509402
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Engineering redirected NF-κB/OIP5 expression programs to enhance tumor responses to chemotherapy in bladder cancer [ Sci Bull (Beijing), 2023, 10.1016/j.scib.2023.11.027]	PubMed: 37993335
Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments [ EMBO Mol Med, 2023, 15(12):e18199]	PubMed: 38037472
TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs [ Cell Death Dis, 2023, 14(1):64]	PubMed: 36707511
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176]	PubMed: 37773750

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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