WASF2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	WASF2 Rabbit Recombinant mAb detects endogenous level of total WASF2.
背景	The Wiskott-Aldrich syndrome (WAS) is a human X-linked primary immunodeficiency characterised by inmunodeficiency, micro-thrombocytopaenia and eczema. WASp gives name to a family of recently defined proteins involved in the signal transduction from the membrane to the actin cytoskeleton as well as in cellular development and activation processes. The gene that causes WAS (WASP) encodes a 502 residues protein designated as WASp. WASp is also a key protein involved in the regulation of signals coming from the TCR/CD3, which drive to T cell transcriptional activation and proliferation. Furthermore, WASp has been involved in thymocyte maturation. WASP family protein member 2 (Wasf2; also known as WASP family verprolin-homologous protein 2; WAVE2) is one of the WASP family proteins which is ubiquitously expressed in mammals. Wasf2 is crucial for Rac-induced membrane ruffling, which is important in cell motility.

特异性

WASF2 Rabbit Recombinant mAb detects endogenous level of total WASF2.

背景

The Wiskott-Aldrich syndrome (WAS) is a human X-linked primary immunodeficiency characterised by inmunodeficiency, micro-thrombocytopaenia and eczema. WASp gives name to a family of recently defined proteins involved in the signal transduction from the membrane to the actin cytoskeleton as well as in cellular development and activation processes. The gene that causes WAS (WASP) encodes a 502 residues protein designated as WASp. WASp is also a key protein involved in the regulation of signals coming from the TCR/CD3, which drive to T cell transcriptional activation and proliferation. Furthermore, WASp has been involved in thymocyte maturation. WASP family protein member 2 (Wasf2; also known as WASP family verprolin-homologous protein 2; WAVE2) is one of the WASP family proteins which is ubiquitously expressed in mammals. Wasf2 is crucial for Rac-induced membrane ruffling, which is important in cell motility.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

80kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck