Bleomycin sulfate
别名: NSC125066 sulfate 中文名称：硫酸博来霉素
Bleomycin Sulfate硫酸博来霉素是一种糖肽类抗生素，一种DNA 合成抑制剂，也是一种鳞状细胞癌(SCC)抗癌剂，在UT-SCC-19A细胞中IC50为4 nM。Bleomycin sulfate是一种DNA 合成抑制剂。Bleomycin (NSC125066) sulfate可用于诱导肺纤维化动物疾病模型。
Bleomycin sulfate Chemical Structure
CAS: 9041-93-4
产品质控
批次：
纯度：
99.96%
99.96
常与Bleomycin sulfate一起在实验中被使用的化合物
Bleomycin sulfate和Lomustine治疗转移性睾丸癌有益。
Sonntag RW, et al. Cancer Chemother Rep. 1975 Mar-Apr;59(2 Pt 1):429-31.
Bleomycin sulfate和Cisplatin联合抑制DNA合成，导致小鼠胚胎成纤维细胞死亡。
Bleomycin sulfate和Carboplatin联合抑制DNA合成，导致小鼠胚胎成纤维细胞死亡。
Bleomycin (NSC125066) sulfate和Doxorubicin对化学诱导的大鼠前胃和膀胱肿瘤有较好的治疗效果。
Tormey DC, et al. Cancer Chemother Rep. 1973 Nov-Dec;57(4):413-8.
Bleomycin (NSC125066) sulfate和Vinblastine联合治疗不可切除的非小细胞肺癌(NSCLC)有效。
Bleomycin sulfate相关产品
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| MDA-MB-235 | PDT/PCI Treatment | 0.25 μg/ml. | 1-4 h | shows significant (P < 0.05) cytotoxic effect | 22591284 |
| MDA-MB-231 | PDT/PCI Treatment | 0.25 μg/ml. | 1-4 h | shows significant (P < 0.05) cytotoxic effect | 22591284 |
| MCF-7 | PDT/PCI Treatment | 0.25 μg/ml. | 1-4 h | shows significant (P < 0.05) cytotoxic effect | 22591284 |
| MCF-7/Her-18 | Growth Inhibition Assay | 0.42-1700 μg/mL | 24 h | inhibits cell growth dose dependently | 22621404 |
| A549 | Function Assay | 100 μM | 0–48 h | decreases MMP and ATP levels | 22773697 |
| A549 | Function Assay | 100 μM | 0–48 h | causes mitochondrial localization of Bax | 22773697 |
| A549 | Function Assay | 100 μM | 0–48 h | causes PKD1 cleavage | 22773697 |
| A549 | Function Assay | 100 μM | 0–48 h | causes caspase-3 activation | 22773697 |
| A549 | Function Assay | 0-400 μM | 2-48 h | causes more mtDNA than nDNA damage | 22773697 |
| 231-H2N | Growth Inhibition Assay | 0–200 μg/mL | 24 h | inhibits cell growth dose dependently | 22819196 |
| MDA-MB-468 | Growth Inhibition Assay | 0–200 μg/mL | 24 h | inhibits cell growth dose dependently | 22819196 |
| NCCIT | Function Assay | 120 μg/ml | 72 h | significantly increases LPO levels | 22825355 |
| NTera-2 | Function Assay | 120 μg/ml | 72 h | significantly increases LPO levels | 22825355 |
| NCCIT | Function Assay | 120 μg/ml | 72 h | significantly increases Protein carbonyl levels | 22825355 |
| NTera-2 | Function Assay | 120 μg/ml | 72 h | significantly increases Protein carbonyl levels | 22825355 |
| NCCIT | Function Assay | 120 μg/ml | 72 h | significantly decreases GSH levels | 22825355 |
| NCCIT | Function Assay | 120 μg/ml | 72 h | significantly increases TBARS levels | 22825355 |
| NTera-2 | Function Assay | 120 μg/ml | 72 h | significantly increases TBARS levels | 22825355 |
| NCCIT | Function Assay | 120 μg/ml | 72 h | significantly increases 8-isoprostane levels | 22825355 |
| NTera-2 | Function Assay | 120 μg/ml | 72 h | significantly increases 8-isoprostane levels | 22825355 |
| NT2 | Apoptosis Assay | 400 µg/ml | 24 h | induces significant increases in caspase-3,8,9 activity | 23386420 |
| NCM460 | Growth Inhibition Assay | 0-100 μg/ml | 48 h | inhibits cell growth dose dependently | 23518201 |
| HCT116 | Growth Inhibition Assay | 0-100 μg/ml | 48 h | inhibits cell growth dose dependently | 23518201 |
| HeLa | Apoptosis Assay | 3/7.5/15 μg/ml | 48 h | reduces the level of BLH at high concentration | 23708668 |
| HCT-116 | Apoptosis Assay | 3/7.5/15 μg/ml | 48 h | reduces the level of BLH at high concentration | 23708668 |
| A549 | Growth Inhibition Assay | 200 μM | 24 h | decreases cell viability significantly | 23805793 |
| MMP1 | Apoptosis Assay | 10 mU | 48 h | induces apoptosis | 23902766 |
| MOCK | Apoptosis Assay | 10 mU | 48 h | induces apoptosis | 23902766 |
| A459 | Apoptosis Assay | 10 mU | 48 h | induces apoptosis | 23902766 |
| BMG-1 | Growth Inhibition Assay | 40/80 μg/m | 3 h | inhibits cell growth dose dependently | 23906726 |
| Jurkat | Growth Inhibition Assay | 20 μm | 24 h | arrests the cell cycle at the G2 phase | 24916893 |
| MLE12 | Function Assay | 1 µg/mL | 0-48 h | increases the expression of OPN mRNA | 24963635 |
| A549 | Function Assay | 1 µg/mL | 0-48 h | increases the expression of OPN mRNA | 24963635 |
| AY-27 | Growth Inhibition Assay | 50-200 IU | 48 h | inhibits cell growth dose dependently | 25101299 |
| T24 | Growth Inhibition Assay | 50-200 IU | 48 h | inhibits cell growth dose dependently | 25101299 |
| A431 | Growth Inhibition Assay | 50-200 IU | 48 h | inhibits cell growth dose dependently | 25101299 |
| HT1080 | Function Assay | 1 μM | 24 h | induces a potent global DNA damage response | 25518961 |
| HT1080 | Growth Inhibition Assay | 1 μM | 24 h | leads to a G2/M delay | 25518961 |
| IMR-32 | Growth Inhibition Assay | 7.5−120 µg/ml | 12−48 h | IC50=60 µg/ml at the end of 24 hrs of incubation | 25536345 |
| PMCs | Function Assay | 0.2 μg/ml | 12/24/48 h | increases cell migration | 25595642 |
| PMCs | Function Assay | 0.2 μg/ml | 72 h | induces decreases in cytokeratin-8 and E-cadherin protein | 25595642 |
| PMCs | Function Assay | 0.2 μg/ml | 24–72 h | induces increases in vimentin and α-SMA protein | 25595642 |
| PMCs | Function Assay | 0.1–2 μg/ml | 24 h | causes a dose-dependent increase in the protein level of collagen-I | 25595642 |
| RLE/Abca3 | Function Assay | 0.4 μM | 144 h | induces a morphological change from epithelial-like morphology to a wide, spread-out morphology | 25760538 |
| F98 | Growth Inhibition Assay | 0–1000 μm | 24 h | inhibits cell growth dose dependently | 26088711 |
| MCF-7 | Growth Inhibition Assay | 0-2 μg/ml. | 24/48 h | EC50=1.2 μg/mL | 22591284 |
| NCCIT | Growth Inhibition Assay | 20–140 μg/ml | 72 h | LD50=120 μg/ml | 22562160 |
| HeLa | Function Assay | 30/70 μg/ml | 24 h | increases the mRNA levels of p53，ATM,p21 and GADD45 | 22487937 |
| MCF-7 | Function Assay | 30/70 μg/ml | 24 h | increases the mRNA levels of p53，ATM,p21 and GADD45 | 22487937 |
| HeLa | Cytotoxicity Assay | 30/70 μg/ml | 24 h | induces highly significant levels of fragmented DNA release into the cytoplasm | 22487937 |
| MCF-7 | Cytotoxicity Assay | 30/70 μg/ml | 24 h | induces highly significant levels of fragmented DNA release into the cytoplasm | 22487937 |
| NT2 | Growth Inhibition Assay | 100-600 μg/ml | 24 h | IC50=400 µg/ml | 22469952 |
| NT2 | Function Assay | 400 μg/ml | 24 h | significantly increases caspase-3,8,9 activity | 22469952 |
| NT2 | Function Assay | 400 μg/ml | 24 h | significantly increases BAX level | 22469952 |
| NT2 | Function Assay | 400 μg/ml | 24 h | significantly decreases Bcl-2 level | 22469952 |
| CHO | Function Assay | 2.5 μg/ml | 18 h/6 d | induces persistence of chromosome damage | 22230195 |
| Jurkat | Growth Inhibition Assay | 0-100 μg/ml | 24 h | arrests the cell cycle at the G2 phase | 22223332 |
| Jurkat | Function Assay | 30 μg/ml | 24 h | increases the protein levels of cyclins D3, A and B1 | 22223332 |
| Jurkat | Growth Inhibition Assay | 0-100 μg/ml | 24 h | inhibits cell proliferation in a dose-dependent manner with an IC50 value of 100μg/mL | 22223332 |
| Jurkat | Function Assay | 30 μg/ml | 24 h | increases the effect of pycnidione on phosphorylation levels of histone H2A.X | 22223332 |
| U2OS EGFPnls | Growth Inhibition Assay | 0-2 μg/ml | 24 h | inhibits cell growth dose dependently | 21811007 |
| U2OS KuEnls | Growth Inhibition Assay | 0-2 μg/ml | 24 h | inhibits cell growth dose dependently | 21811007 |
| MCF-7 | Growth Inhibition Assay | 0-400 μM | 72 h | LC50=151.8 μM | 21703291 |
| MCF-7/Adr | Growth Inhibition Assay | 0-400 μM | 72 h | LC50=58.5 μM | 21703291 |
| WI-38 | Function Assay | 0/40/80 μg/ml | 3 h | induces a concentration-dependent increase in the MN frequency | 21599612 |
| hBMSC | Function Assay | 0/40/80 μg/ml | 3 h | induces a concentration-dependent increase in the MN frequency | 21599612 |
| NCI-H23 | Function Assay | 0/40/80 μg/ml | 3 h | induces a concentration-dependent increase in the MN frequency | 21599612 |
| A-549 | Function Assay | 0/40/80 μg/ml | 3 h | induces a concentration-dependent increase in the MN frequency | 21599612 |
| PBL | Function Assay | 0/40/80 μg/ml | 3 h | induces a concentration-dependent increase in the MN frequency | 21599612 |
| pol β −/− | Growth Inhibition Assay | 0.25-200 μg/ml | 24 h | decreases cell viability with increasing concentrations | 21251944 |
| pol β +/+ | Growth Inhibition Assay | 0.25-200 μg/ml | 24 h | decreases cell viability with increasing concentrations | 21251944 |
| pol β −/− | Function Assay | 0-2.5 μg/ml | 2 h | causes DNA damage | 21251944 |
| pol β +/+ | Function Assay | 0-2.5 μg/ml | 2 h | causes DNA damage | 21251944 |
| pol β −/− | Function Assay | 0-5 μg/ml | 48 h | causes micronucleus dose and time dependently | 21251944 |
| pol β +/+ | Function Assay | 0-5 μg/ml | 48 h | causes micronucleus dose and time dependently | 21251944 |
| TK6 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | inhibits cell growth dose dependently | 21081487 |
| TK6 sLUC+Apn1 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | inhibits cell growth dose dependently | 21081487 |
| TK6 sAPE1+Apn1 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | significantly inhibits cell growth dose dependently | 21081487 |
| HCT116 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | inhibits cell growth dose dependently | 21081487 |
| HCT116 sLUC+Apn1 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | inhibits cell growth dose dependently | 21081487 |
| HCT116 sAPE1+Apn1 | Growth Inhibition Assay | 25-150 μg/ml | 96 h | significantly inhibits cell growth dose dependently | 21081487 |
| A549 | Function Assay | 200/400 μM | results in a dose-responsive increase in ROS | 22773697 | |
| C18-4 | Growth Inhibition Assay | 0-100 μM | inhibits cell growth dose dependently | 24571982 | |
| NT2 | Growth Inhibition Assay | 72 h | LD50=20 µg/ml | 23386420 | |
| NT2 | Growth Inhibition Assay | 48 h | LD50=100 µg/ml | 23386420 | |
| NT2 | Growth Inhibition Assay | 24 h | LD50=400 µg/ml | 23386420 | |
| HCT116 | Cytotoxicity Assay | 72 h | IC50=11.34% | 25276792 | |
| HT-29 | Cytotoxicity Assay | 72 h | IC50=11.49% | 25276792 | |
| THP-1 | Cytotoxicity Assay | 72 h | IC50=4.77% | 25276792 | |
| HDFn | Cytotoxicity Assay | 72 h | IC50=9.31% | 25276792 | |
| NCCIT | Function Assay | 72 h | significantly increases caspase-3 activity | 22562160 | |
| NCCIT | Function Assay | 72 h | significantly increases caspase-8 activity | 22562160 | |
| NCCIT | Function Assay | 72 h | significantly increases caspase-9 activity | 22562160 | |
| NCCIT | Function Assay | 72 h | significantly increases BAX level | 22562160 | |
| NCCIT | Function Assay | 72 h | significantly decreases the Bcl-2 content | 22562160 | |
| NCCIT | Function Assay | 72 h | significantly decreases the Cyt-c level | 22562160 | |
| 2SC/20 | Function Assay | 72 h | IC50 = 0.517 μM | 12431060 | |
| HET-SR-2SC-LNM | Function Assay | 72 h | IC50 = 0.519 μM | 12431060 | |
| MCF-7 | Function Assay | 24 h | IC50 = 53 μM | 12477361 | |
| HeLa | Growth Inhibition Assay | IC50=10.2 μM | 24732397 | ||
| POLK CD | Growth Inhibition Assay | IC50=5.59 ± 1.00 μM | 26031400 | ||
| POLK KO | Growth Inhibition Assay | IC50=4.03 ± 1.92 μM | 26031400 | ||
| POLK WT | Growth Inhibition Assay | IC50=11.7 ± 1.7 μM | 26031400 | ||
| HepG2 | Growth Inhibition Assay | GI50 = 1 μM | 18068362 | ||
| COLO-668 | Growth Inhibition Assay | IC50 = 0.0000218 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50 = 0.000099 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50 = 0.000118 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50 = 0.0001319 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50 = 0.0001358 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50 = 0.0001391 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50 = 0.0001732 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50 = 0.0001777 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50 = 0.000251 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50 = 0.000254 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50 = 0.0003147 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50 = 0.0004527 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50 = 0.0004763 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50 = 0.0005457 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50 = 0.0005873 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50 = 0.00108 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50 = 0.001643 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50 = 0.002646 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50 = 0.002647 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50 = 0.003712 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50 = 0.004134 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50 = 0.00422 μM | SANGER | ||
| RT4 | Growth Inhibition Assay | IC50 = 0.005856 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50 = 0.006293 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50 = 0.006592 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50 = 0.00685 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50 = 0.006853 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50 = 0.007647 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50 = 0.008543 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50 = 0.009572 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50 = 0.009908 μM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50 = 0.009935 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50 = 0.01084 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50 = 0.01185 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50 = 0.01339 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50 = 0.01383 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50 = 0.01383 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50 = 0.01477 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50 = 0.01612 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50 = 0.01634 μM | SANGER | ||
| NCI-H1734 | Growth Inhibition Assay | IC50 = 0.01742 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50 = 0.02139 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50 = 0.02481 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50 = 0.0267 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50 = 0.02685 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50 = 0.02694 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50 = 0.02897 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50 = 0.02967 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50 = 0.03124 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50 = 0.03255 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50 = 0.03826 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50 = 0.04357 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50 = 0.05276 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50 = 0.05514 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50 = 0.05909 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50 = 0.06974 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50 = 0.0711 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50 = 0.07117 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50 = 0.07548 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50 = 0.07651 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50 = 0.07869 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50 = 0.07965 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50 = 0.08036 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50 = 0.0805 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50 = 0.08084 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50 = 0.08162 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50 = 0.08304 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50 = 0.08831 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50 = 0.0951 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50 = 0.10452 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50 = 0.10753 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50 = 0.10855 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50 = 0.11074 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50 = 0.1228 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50 = 0.1305 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50 = 0.13057 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50 = 0.13146 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50 = 0.13166 μM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50 = 0.13698 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50 = 0.13715 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50 = 0.13736 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50 = 0.13888 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50 = 0.14398 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50 = 0.14455 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50 = 0.14774 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50 = 0.15221 μM | SANGER | ||
| MFE-296 | Growth Inhibition Assay | IC50 = 0.15324 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50 = 0.16242 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50 = 0.17196 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50 = 0.17534 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50 = 0.18225 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50 = 0.18269 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50 = 0.18744 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50 = 0.19067 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50 = 0.20037 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50 = 0.21956 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50 = 0.22019 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50 = 0.22434 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50 = 0.22845 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50 = 0.23357 μM | SANGER | ||
| SK-CO-1 | Growth Inhibition Assay | IC50 = 0.24652 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50 = 0.24925 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50 = 0.25606 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50 = 0.25851 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50 = 0.26047 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50 = 0.27307 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50 = 0.27975 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50 = 0.28935 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50 = 0.29208 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50 = 0.29533 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50 = 0.29644 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50 = 0.31639 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50 = 0.32074 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50 = 0.37271 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50 = 0.37463 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50 = 0.37669 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50 = 0.37688 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50 = 0.37754 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50 = 0.37834 μM | SANGER | ||
| C-4-II | Growth Inhibition Assay | IC50 = 0.38131 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50 = 0.38851 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50 = 0.39011 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50 = 0.39305 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50 = 0.39549 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50 = 0.39872 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50 = 0.40625 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50 = 0.41411 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50 = 0.41493 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50 = 0.41539 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50 = 0.41743 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50 = 0.42016 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50 = 0.42569 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50 = 0.42616 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50 = 0.43178 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50 = 0.44079 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50 = 0.44505 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50 = 0.45232 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50 = 0.45316 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50 = 0.47988 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50 = 0.49938 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50 = 0.50094 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50 = 0.50253 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50 = 0.5053 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50 = 0.50539 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50 = 0.50953 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50 = 0.521 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50 = 0.52424 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50 = 0.53464 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50 = 0.5355 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50 = 0.54612 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50 = 0.54993 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50 = 0.5602 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50 = 0.56023 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50 = 0.57104 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50 = 0.57224 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50 = 0.58605 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50 = 0.60449 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50 = 0.61972 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50 = 0.62043 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50 = 0.62355 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50 = 0.63315 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50 = 0.63656 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50 = 0.64101 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50 = 0.64336 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50 = 0.64425 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50 = 0.68829 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50 = 0.69103 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50 = 0.71228 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50 = 0.7169 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50 = 0.71692 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50 = 0.71885 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50 = 0.71909 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50 = 0.71991 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50 = 0.73154 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50 = 0.73825 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50 = 0.74272 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50 = 0.74583 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50 = 0.77232 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50 = 0.77431 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50 = 0.78312 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50 = 0.79823 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50 = 0.80316 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50 = 0.80431 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50 = 0.80768 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50 = 0.80834 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50 = 0.82255 μM | SANGER | ||
| SNG-M | Growth Inhibition Assay | IC50 = 0.83083 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50 = 0.83182 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50 = 0.85021 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50 = 0.85391 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50 = 0.85487 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50 = 0.86739 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50 = 0.87048 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50 = 0.87718 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50 = 0.92254 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50 = 0.92472 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50 = 0.93436 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50 = 0.95465 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50 = 0.95561 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50 = 0.98627 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50 = 0.99291 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50 = 0.99868 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50 = 0.99868 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50 = 1.03998 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50 = 1.06873 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50 = 1.09156 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50 = 1.13021 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50 = 1.13172 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50 = 1.16584 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50 = 1.20001 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50 = 1.21374 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50 = 1.24443 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50 = 1.26178 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50 = 1.26806 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50 = 1.26828 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50 = 1.27996 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50 = 1.29359 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50 = 1.30544 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50 = 1.3128 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50 = 1.31567 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50 = 1.31797 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50 = 1.37884 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50 = 1.39853 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50 = 1.39929 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50 = 1.40825 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50 = 1.43514 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50 = 1.45252 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50 = 1.45278 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50 = 1.47953 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50 = 1.48966 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50 = 1.49578 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50 = 1.51005 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50 = 1.57595 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50 = 1.60642 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50 = 1.60859 μM | SANGER | ||
| EHEB | Growth Inhibition Assay | IC50 = 1.60861 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50 = 1.60892 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50 = 1.67096 μM | SANGER | ||
| MES-SA | Growth Inhibition Assay | IC50 = 1.67344 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50 = 1.68921 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50 = 1.73341 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50 = 1.77334 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50 = 1.81357 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50 = 1.81784 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50 = 1.82747 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50 = 1.84743 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50 = 1.85749 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50 = 1.93424 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50 = 1.95452 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50 = 2.00542 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50 = 2.01527 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50 = 2.03812 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50 = 2.04945 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50 = 2.05402 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50 = 2.11053 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50 = 2.11197 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50 = 2.14352 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50 = 2.14602 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50 = 2.17066 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50 = 2.18726 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50 = 2.20714 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50 = 2.20811 μM | SANGER | ||
| IPC-298 | Growth Inhibition Assay | IC50 = 2.21227 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50 = 2.25537 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50 = 2.28651 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50 = 2.31888 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50 = 2.31957 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50 = 2.32484 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50 = 2.34633 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50 = 2.34738 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50 = 2.41593 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50 = 2.4302 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50 = 2.43456 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50 = 2.46672 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50 = 2.46688 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50 = 2.55034 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50 = 2.56438 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50 = 2.56683 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50 = 2.57186 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50 = 2.65761 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50 = 2.66172 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50 = 2.68962 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50 = 2.73884 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50 = 2.74098 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50 = 2.75256 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50 = 2.767 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50 = 2.78722 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50 = 2.83188 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50 = 2.83636 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50 = 2.84084 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50 = 2.85522 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50 = 2.88305 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50 = 2.92149 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50 = 2.94674 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50 = 2.96422 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50 = 2.96513 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50 = 2.98076 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50 = 2.99693 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50 = 3.02325 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50 = 3.03067 μM | SANGER | ||
| EW-7 | Growth Inhibition Assay | IC50 = 3.05866 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50 = 3.07459 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50 = 3.08914 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50 = 3.14297 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50 = 3.20606 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50 = 3.22315 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50 = 3.22456 μM | SANGER | ||
| COLO-205 | Growth Inhibition Assay | IC50 = 3.24454 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50 = 3.25583 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50 = 3.26145 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50 = 3.2899 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50 = 3.34045 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50 = 3.36875 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50 = 3.38494 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50 = 3.4017 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50 = 3.43354 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50 = 3.45241 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50 = 3.55738 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50 = 3.76703 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50 = 3.79836 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50 = 3.80576 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50 = 3.81218 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50 = 3.89603 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50 = 3.91812 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50 = 3.99693 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50 = 4.05162 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50 = 4.1047 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50 = 4.13195 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50 = 4.20151 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50 = 4.24402 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50 = 4.27798 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50 = 4.28656 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50 = 4.30277 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50 = 4.33027 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50 = 4.36314 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50 = 4.41035 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50 = 4.41781 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50 = 4.44726 μM | SANGER | ||
| CCF-STTG1 | Growth Inhibition Assay | IC50 = 4.56209 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50 = 4.59384 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50 = 4.60119 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50 = 4.74899 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50 = 4.75506 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50 = 4.79184 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50 = 4.88426 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50 = 4.91668 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50 = 4.92002 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50 = 4.94112 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50 = 4.99065 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50 = 5.11661 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50 = 5.11905 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50 = 5.13773 μM | SANGER | ||
| Calu-1 | Growth Inhibition Assay | IC50 = 5.13779 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50 = 5.21763 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50 = 5.28851 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50 = 5.29092 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50 = 5.54575 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50 = 5.55505 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50 = 5.56142 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50 = 5.67305 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50 = 5.7583 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50 = 5.77714 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50 = 5.91176 μM | SANGER | ||
| NCI-H838 | Growth Inhibition Assay | IC50 = 5.94757 μM | SANGER | ||
| NCI-H1618 | Growth Inhibition Assay | IC50 = 5.98557 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50 = 6.08459 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50 = 6.19074 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50 = 6.39405 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50 = 6.41293 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50 = 6.42507 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50 = 6.72078 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50 = 6.78617 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50 = 6.78887 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50 = 6.93011 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50 = 6.96614 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50 = 7.09344 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50 = 7.09585 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50 = 7.32932 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50 = 7.34054 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50 = 7.36534 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50 = 7.67159 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50 = 7.77036 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50 = 7.84755 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50 = 7.9095 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50 = 7.96408 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50 = 8.07296 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50 = 8.1465 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50 = 8.20414 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50 = 8.38272 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50 = 8.48548 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50 = 8.5506 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50 = 9.04985 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50 = 9.18802 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50 = 9.20646 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50 = 9.26 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50 = 9.73755 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50 = 9.88105 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50 = 10.3102 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50 = 10.4566 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50 = 10.6436 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50 = 10.8362 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50 = 10.9343 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50 = 11.0572 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50 = 11.1604 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50 = 11.3757 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50 = 11.455 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50 = 11.5965 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50 = 11.7421 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50 = 11.8941 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50 = 11.931 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50 = 12.0521 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50 = 12.3857 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50 = 12.7546 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50 = 13.0065 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50 = 13.3146 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50 = 13.4592 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50 = 13.5755 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50 = 13.5799 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50 = 13.8464 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50 = 14.1975 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50 = 14.3177 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50 = 14.6341 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50 = 14.7963 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50 = 15.4155 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50 = 15.636 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50 = 15.9419 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50 = 16.0521 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50 = 16.3642 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50 = 16.4227 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50 = 16.565 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50 = 16.9142 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50 = 17.5247 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50 = 18.3155 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50 = 18.5014 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50 = 18.8518 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50 = 18.8813 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50 = 18.9202 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50 = 19.4673 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50 = 19.6679 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50 = 20.3205 μM | SANGER | ||
| Caov-3 | Growth Inhibition Assay | IC50 = 20.4613 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50 = 20.6061 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50 = 21.24 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50 = 21.327 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50 = 21.4262 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50 = 21.8331 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50 = 22.1755 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50 = 22.8494 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50 = 23.0977 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50 = 23.239 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50 = 23.2952 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50 = 23.4283 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50 = 23.4421 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50 = 23.5493 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50 = 24.2155 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50 = 24.5232 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50 = 24.6153 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50 = 25.288 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50 = 25.3526 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50 = 25.9179 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50 = 26.001 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50 = 26.337 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50 = 26.4052 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50 = 26.9253 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50 = 27.0943 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50 = 27.172 μM | SANGER | ||
| HCC1143 | Growth Inhibition Assay | IC50 = 27.1918 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50 = 27.2024 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50 = 27.3627 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50 = 27.6315 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50 = 28.9662 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50 = 29.1374 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50 = 29.5165 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50 = 30.2856 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50 = 30.3916 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50 = 30.7398 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50 = 31.634 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50 = 31.88 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50 = 32.9082 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50 = 33.4435 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50 = 33.9766 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50 = 34.3161 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50 = 35.2849 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50 = 35.3757 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50 = 36.1155 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50 = 36.2389 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50 = 36.744 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50 = 36.9718 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50 = 38.7612 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50 = 39.0477 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50 = 39.7268 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50 = 39.8805 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50 = 40.8628 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50 = 41.7959 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50 = 41.8216 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50 = 41.8898 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50 = 43.8822 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50 = 46.0431 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50 = 48.6853 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50 = 49.4076 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50 = 52.3358 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50 = 52.489 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50 = 53.329 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50 = 54.5851 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50 = 55.1277 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50 = 56.4075 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50 = 56.7007 μM | SANGER | ||
| TT | Growth Inhibition Assay | IC50 = 59.1501 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50 = 60.2794 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50 = 63.7348 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50 = 65.6647 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50 = 65.7504 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50 = 66.5296 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50 = 67.3338 μM | SANGER | ||
| SNU-475 | Growth Inhibition Assay | IC50 = 67.5008 μM | SANGER | ||
| MDA-MB-468 | Growth Inhibition Assay | IC50 = 67.5522 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50 = 67.9601 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50 = 70.5644 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50 = 72.3646 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50 = 73.2129 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50 = 73.4243 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50 = 74.14 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50 = 75.1768 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50 = 75.8498 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50 = 77.3602 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50 = 77.8428 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50 = 81.0296 μM | SANGER | ||
| SNU-C1 | Growth Inhibition Assay | IC50 = 81.9941 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50 = 82.3997 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50 = 82.5028 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50 = 84.163 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50 = 84.7528 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50 = 84.8498 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50 = 85.5708 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50 = 85.7672 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50 = 87.8298 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50 = 90.2444 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50 = 91.8016 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50 = 92.4868 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50 = 93.3592 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50 = 95.3316 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50 = 99.5951 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50 = 103.351 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50 = 103.909 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50 = 104.066 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50 = 105.698 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50 = 110.224 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50 = 123.332 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50 = 125.868 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50 = 126.132 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50 = 126.227 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50 = 129.777 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50 = 136.469 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50 = 142.135 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50 = 142.206 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50 = 147.962 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50 = 149.459 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Bleomycin Sulfate硫酸博来霉素是一种糖肽类抗生素，一种DNA 合成抑制剂，也是一种鳞状细胞癌(SCC)抗癌剂，在UT-SCC-19A细胞中IC50为4 nM。Bleomycin sulfate是一种DNA 合成抑制剂。Bleomycin (NSC125066) sulfate可用于诱导肺纤维化动物疾病模型。 |
|---|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | UT-SCC-12A和 UT-SCC-12B均对Bleomycin sulfate耐药，IC50分别为14.2 nM 和13 nM。[1]肺泡巨噬细胞与0.01 μg/mL到1μg /mL Bleomycin sulfate培养18小时显著比巨噬细胞单独培养分泌更多的成纤维细胞生长因子。Bleomycin sulfate刺激的巨噬细胞持续产生大量成纤维细胞生长因子，即使在移去Bleomycin sulfate，用新鲜培养基(不含Bleomycin sulfate)取代之后，该作用依然存在。Bleomycin sulfate刺激肺泡巨噬细胞导致的纤维素生长因子分泌被环己酰亚胺，和5-脂氧合酶抑制剂NDGA(去甲二氢愈创木酸)和BW755c抑制，表明其不仅需要蛋白质合成，也需要花生四烯酸代谢的5-脂氧合酶途径活性完全表达。[2] Bleomycin sulfate (400 µg/mL)培养24小时，降低NTera-2细胞的活性，增加caspase-3，-8和-9的活性，增加Bax和细胞质细胞色素C水平，并降低Bcl-2水平。[3]对于不稳定性畸变，Bleomycin sulfate对ADIPO-P2细胞的致染色体断裂作用在处理后至少持续10天。此外，暴露于Bleomycin sulfate的细胞处理10天后，端粒融合体的外观表明Bleomycin sulfate能够诱导延迟的端粒失稳。[4] |
|||
|---|---|---|---|---|
| 细胞实验 | 细胞系 | ADIPO-P2 细胞 | ||
| 浓度 | 2.5 μg/mL | |||
| 孵育时间 | 30分钟 | |||
| 方法 | ADIPO-P2细胞在D-MEM高葡萄糖培养基中生长，用20%胎牛血清，青霉素(100 U/mL) 和链霉素 (100 μg/mL)增补，在37 °C 和5% CO2大气环境中培养。细胞在包含1.5×105 cells/mL的TC25 Corning培养瓶中单层培养。对于每个实验，建立两个培养瓶，一个用于对照组，一个用于处理培养。在对数生长期，ADIPO-P2细胞用2.5 μg/mL Bleomycin sulfate以30分钟脉冲处理。建立平行对照组，不暴露于Bleomycin sulfate。暴露时间和Bleomycin sulfate浓度根据先前实验室中进行的Bleomycin sulfate处理哺乳动物细胞的研究进行选择。Bleomycin sulfate脉冲处理结束时，细胞用Hank's平衡盐溶液清洗两次，并保存在新鲜培养基中直到采集。处理后5个传代培养期间，将细胞持续保持在培养基中。当培养基中融合(培养基中大约4×105 cells/mL)时，进行传代培养。为估计细胞生长，传代培养时，细胞通过胰蛋白酶化收集，每等份大约200 μL，用0.4%台盼蓝着色，测定活细胞数量。随后细胞悬浮在新鲜培养基中，重新分配到包含1×105 cells/mL的新培养瓶中继续生长。将剩余的细胞丢弃或置于另外的培养瓶中进行细胞遗传学分析，这在处理结束后18小时或第10天进行。为分析染色体突变，培养的最后3小时将colchicine (0.1 μg/mL)加入到细胞培养基。染色体的制备根据标准程序进行。采集后，将细胞低渗震动，固定在甲醇:乙酸(3:1)中，涂布在载玻片上，进行PNA-FISH。进行两个独立的实验。 |
|||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | LRP6 / Wnt5AB / Dvl2 / β-catenin phospho-eIF2α / eIF2α cytochrome c Bcl-xl Bcl-2 |
|
27649046 | |
| Immunofluorescence | LC3 |
|
23762310 | |
| ELISA | HMGB1 |
|
23762310 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | Bleomycin sulfate处理后第7天，NOX-/- 的BALf中CD45+细胞是WT的1.7倍多，其中57%为Mf，第21天，在WT中减少到67%，在NOX-/-中减少到83%。[5] |
|
|---|---|---|
| 动物实验 | Animal Models | CD-1小鼠 |
| Dosages | 5 mg/kg, 2 ml/kg | |
| Administration | 鞘内注射给药 | |
化学信息&溶解度
| 分子量 | 1512.62 | 分子式 | C55H85N17O25S4 |
| CAS号 | 9041-93-4 | SDF | Download Bleomycin sulfate SDF |
| Smiles | CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-] | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 100 mg/mL ( (66.11 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : 25 mg/mL (16.52 mM) Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
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常见问题及建议解决方法
问题 1:
what is the ratio between bleomycin A2 and bleomycin B2 in your product?
回答：
The content of Bleomycin A2 and Bleomycin B2 is 62% and 29% respectively.
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