Laduviglusib (CHIR-99021) HCl
别名: CT99021 HCl
Laduviglusib (CHIR-99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂，IC50为10 nM/6.7 nM。其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。CHIR-99021 是一种有效的药理性的 Wnt/beta-catenin 信号通路的激活剂。CHIR-99021 可显著地拯救光诱导的 autophagy，并可增强 GR，RORα和自噬相关蛋白等表达。
Laduviglusib (CHIR-99021) HCl Chemical Structure
CAS: 1797989-42-4
客户使用Selleck的Laduviglusib (CHIR-99021) HCl发表文献648篇
产品质控
批次：
纯度：
99.97%
99.97
常与Laduviglusib (CHIR-99021) HCl一起在实验中被使用的化合物
Laduviglusib HCl介导的糖原合成酶激酶(GSK3)抑制使结直肠癌(CRC)细胞HCT-15对Olaparib敏感。
Laduviglusib HCl和Y-27632 2HCl及其他小分子，促进来自成人和新生儿来源的间充质干细胞的神经元诱导。
Cortés-Medina LV, et al. Stem Cells Int. 2019 Apr 1;2019:7627148.
Laduviglusib HCl上调β-catenin的总量和活性量，而IWR1-endo降低CASCs和SW480细胞中β-catenin的活性表达。
Laduviglusib HCl和MG132作为蛋白质稳定性探针，在鉴定短半衰期蛋白的调节因子中发挥关键作用。
Laduviglusib HCl和IWP-2，在人诱导多能干细胞(hiPSC)向心肌细胞的分化过程中起着至关重要的作用。
Laduviglusib (CHIR-99021) HCl相关产品
| 相关靶点 | GSK-3α GSK-3β | 点击展开 |
|---|---|---|
| 相关化合物库 | 激酶抑制剂库 PI3K/Akt 抑制剂库 凋亡分子化合物库 细胞周期化合物库 NF-κB信号通路库 | 点击展开 |
相关信号通路图
GSK-3抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| ES-CCE | Function Assay | 5 μM | 3 d | Strongly induces the activity of Wnt/beta-catenin pathway | 24779365 |
| ES-D3 | Function Assay | 5 μM | 3 d | Strongly induces the activity of Wnt/beta-catenin pathway | 24779365 |
| ES-CCE | Cytotoxic Assay | 10 μM | 3 d | Induces moderate cytotoxicity | 24779365 |
| ES-D3 | Cytotoxic Assay | 10 μM | 3 d | Induces moderate cytotoxicity with IC50 of 4.9 μM | 24779365 |
| Neural progenitor cells | Function Assay | 3 μM | 10 d | Induces generation of neural progenitor cells | 24638034 |
| A549 | Apoptosis Assay | 5 µM | 24 h | Increases cell apoptosis | 24367688 |
| H157 | Apoptosis Assay | 5 µM | 24 h | Does not significantly affect apoptosis | 24367688 |
| H460 | Apoptosis Assay | 5 µM | 24 h | Attenuates cell apoptosis | 24367688 |
| H157 | Growth Inhibition Assay | 5 µM | 24 h | Promotes cell proliferation | 24367688 |
| H460 | Growth Inhibition Assay | 5 µM | 24 h | Promotes cell proliferation | 24367688 |
| embryonic stem cells (ESC) | Function Assay | 3 µM | 11 d | Promotes self-renewal of naïve-type mouse embryonic stem cells (ESC) | 23843312 |
| DN3 | Function Assay | 10 μM | 96 h | Increases cell development and proliferation | 23526989 |
| platelets | Function Assay | 10 μM | 15 min | Increases thrombin-mediated platelet aggregation and ATP secretion | 23239877 |
| hiPSC-NPs | Growth Inhibition Assay | 3 μM | 72 h | Increases cell proliferation | 22642687 |
| INS-1E | Function Assay | 2.5 μM | 24 h | Induces a reduction of NP1 overexpression | 22427704 |
| PANC1 | Apoptosis Assay | 5 μM | 72 h | Triggers an apoptotic response | 22201186 |
| HMC1.2 | Growth Inhibition Assay | 30 μM | 72 h | Reduces cell survival | 22039301 |
| Sca-1+ HPC | Growth Inhibition Assay | 2 μM | 6 d | Synergistically promotes Sca-1+ HPC proliferation and colony formation together with EGF | 21624348 |
| Oct4/Sox2/Klf4-infected MEFs | Function Assay | 10 μM | 28 d | Promotes MEFs reprogramming Transduced by Oct4, Sox2, and Klf4 | 19839055 |
| H4IIE | Function Assay | 10 μM | 24 h | Regulates β-catenin activity and TIRE containing promoter activity | 15350195 |
| insulin receptor–expressing CHO-IR | Function Assay | 500 nM | 30 min | Activates Glycogen Synthase (GS) | 12606497 |
| 3T3-L1 | Function Assay | 3 μM | 4 h | Inhibits preadipocyte differentiation | 12055200 |
| Endothelial cell(EC) | Function Assay | 3 μM | Promotes endothelial cell (EC) differentiation | 22052006 | |
| CHO-IR | Function Assay | 30 min | EC50=0.77 μM | 29016121 | |
| HepG2 | Function Assay | 3 h | EC50=1.5 μM | 22261023 | |
| LOUCY | Growth Inhibition Assay | IC50=182.688 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=182.829 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=184.631 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=184.643 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=184.651 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=184.972 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=185.145 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=185.209 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=186.941 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=187.392 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=187.453 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=188.428 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=188.719 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=189.798 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=190.181 μM | SANGER | ||
| NCI-H838 | Growth Inhibition Assay | IC50=190.34 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=190.992 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=192.891 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=193.157 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=195.538 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=195.677 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=195.818 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=196.734 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=196.26 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=197.424 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=197.822 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=198.033 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=198.419 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=199.192 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=200.116 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=200.515 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=200.859 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=201.587 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=200.902 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=201.961 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=202.073 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=202.553 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=203.027 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=203.879 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=204.833 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=205.467 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=206.73 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=209.671 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=209.678 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=209.897 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=210.381 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=210.763 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=210.986 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=211.299 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=211.533 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=212.894 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=214.185 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=214.878 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=215.575 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=217.43 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=217.836 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=217.893 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=218.9 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=219.606 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=220.353 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=220.577 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=220.799 μM | SANGER | ||
| NCI-H1618 | Growth Inhibition Assay | IC50=221.018 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=221.251 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=221.377 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=222.239 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=222.389 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=222.523 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=223.796 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=224.389 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=226.53 μM | SANGER | ||
| NCI-H322M | Growth Inhibition Assay | IC50=228.019 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=228.13 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=232.897 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=233.003 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=233.276 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=234.253 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=234.41 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=235.177 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=235.741 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=236.02 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=236.873 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=237.868 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=241.209 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=241.907 μM | SANGER | ||
| IPC-298 | Growth Inhibition Assay | IC50=242.072 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=242.616 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=242.991 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=243.118 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=245.038 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=246.043 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=247.013 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=247.517 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=248.156 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=249.495 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=250.412 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=250.864 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=251.417 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=252.875 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=253.156 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=253.485 μM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=256.76 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=258.584 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=260.272 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=260.996 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=261.192 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=261.918 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=267.025 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=267.941 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=268.366 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=269.119 μM | SANGER | ||
| MDA-MB-468 | Growth Inhibition Assay | IC50=269.333 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=269.708 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=269.92 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=270.358 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=275.457 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=276.439 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=276.461 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=277.405 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=278.279 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=279.187 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=280.54 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=283.058 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=283.123 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=283.953 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=284.665 μM | SANGER | ||
| EW-7 | Growth Inhibition Assay | IC50=285.232 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=286.035 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=287.183 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=290.602 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=291.069 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=292.146 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=292.879 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=295.597 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=295.769 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=296.115 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=296.425 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=298.438 μM | SANGER | ||
| RL95-2 | Growth Inhibition Assay | IC50=300.247 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=300.691 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=301.818 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=302.893 μM | SANGER | ||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=304.907 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=306.017 μM | SANGER | ||
| ECC12 | Growth Inhibition Assay | IC50=310.254 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=312.022 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=312.189 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=313.521 μM | SANGER | ||
| SNU-475 | Growth Inhibition Assay | IC50=314.091 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=314.673 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=315.38 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=320.07 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=321.403 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=321.409 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=322.424 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=322.452 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=323.175 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=323.434 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=323.582 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=324.111 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=326.489 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=326.738 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=328.164 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=330.265 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=332.418 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=334.339 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=336.591 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=336.977 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=337.32 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=337.47 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=338.155 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=338.38 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=338.412 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=341.418 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=341.609 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=342.636 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=343.733 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=344.422 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=345.58 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=345.812 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=345.879 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=346.65 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=347.426 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=349.846 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=351.28 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=352.624 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=353.063 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=355.356 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=356.529 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=357.863 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=358.521 μM | SANGER | ||
| DMS-53 | Growth Inhibition Assay | IC50=358.711 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=359.987 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=360.939 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=363.924 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=372.926 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=373.132 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=376.964 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=378.161 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=383.677 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=385.34 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=390.641 μM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=391.893 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=393.948 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=394.406 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=397.254 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=398.69 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=403.083 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=408.458 μM | SANGER | ||
| MES-SA | Growth Inhibition Assay | IC50=409.98 μM | SANGER | ||
| NCI-H716 | Growth Inhibition Assay | IC50=410.075 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=410.497 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=414.086 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=424.388 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=431.033 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=435.09 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=438.54 μM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=439.429 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=448.888 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=449.68 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=452.888 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=454.385 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=454.507 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=455.297 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=455.699 μM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=456.822 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=457.186 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=460.841 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=463.943 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=464.847 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=472.28 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=474.788 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=477.08 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=480.869 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=488.924 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=489.004 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=491.398 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=502.063 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=502.169 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=504.407 μM | SANGER | ||
| EHEB | Growth Inhibition Assay | IC50=507.208 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=510.021 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=511.101 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=511.416 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=512.439 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=512.705 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=515.116 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=522.924 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=523.064 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=524.696 μM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=525.513 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=526.43 μM | SANGER | ||
| NCI-H2227 | Growth Inhibition Assay | IC50=530.254 μM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=539.293 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=542.442 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=543.684 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=547.23 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=551.35 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=552.399 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50=559.391 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=565.089 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=579.213 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=600.671 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=603.587 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=606.579 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=618.221 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=622.785 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=628.353 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=648.064 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=651.541 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=671.322 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=680.462 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=690.172 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=694.585 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=699.059 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=700.838 μM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=789.315 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=805.203 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=818.059 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=900.231 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=182.387 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=181.934 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=181.672 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=181.66 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=181.059 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=179.432 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=177.846 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=177.806 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=177.561 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=176.555 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=176.399 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=175.861 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=174.863 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=174.016 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=173.848 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=172.273 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=171.535 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=171.032 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=169.891 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=169.636 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=168.415 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=168.311 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=167.451 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=168.309 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=167.354 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=165.45 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=164.321 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=163.64 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=163.626 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=162.613 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=160.584 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=159.583 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=159.396 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=159.242 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=157.369 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=156.694 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=156.077 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=155.821 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=155.183 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=154.772 μM | SANGER | ||
| Calu-1 | Growth Inhibition Assay | IC50=154.003 μM | SANGER | ||
| TT | Growth Inhibition Assay | IC50=153.49 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=153.164 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=152.764 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=151.374 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=151.135 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=150.209 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=149.75 μM | SANGER | ||
| Caov-3 | Growth Inhibition Assay | IC50=149.714 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=149.443 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=148.705 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=148.562 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=148.54 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=148.247 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=147.797 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=147.441 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=147.404 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=147.253 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=147.143 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=145.967 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=145.835 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=145.075 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=144.005 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=143.687 μM | SANGER | ||
| CCF-STTG1 | Growth Inhibition Assay | IC50=143.334 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=142.889 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=141.798 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=141.507 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=141.466 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=140.749 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=140.208 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=138.831 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=137.856 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=135.295 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=134.765 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=134.59 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=134.359 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=134.2 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=134.116 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=133.975 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=132.897 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=132.204 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=131.114 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=130.375 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=129.931 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=129.198 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=127.013 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=126.038 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=124.283 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=124.077 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=123.176 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=122.778 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=122.499 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=122.141 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=121.55 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=121.044 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=119.915 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=119.417 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=118.956 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=118.116 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=117.898 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=117.828 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=117.668 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=117.156 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=116.798 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=115.617 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=113.453 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=113.125 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=112.624 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=112.49 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=112.065 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=112.01 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=110.661 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=110.479 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=109.945 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=108.961 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=108.488 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=108.475 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=108.357 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=106.85 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=106.678 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=105.023 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=103.842 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=103.584 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=102.95 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=101.762 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=101.724 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=101.437 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=101.081 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=99.5603 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=99.3119 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=99.3004 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=99.0564 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=98.9489 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=97.7439 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=97.461 μM | SANGER | ||
| Caov-4 | Growth Inhibition Assay | IC50=95.685 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=95.4617 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=95.1072 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=94.954 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=94.5984 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=93.7811 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=93.168 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=93.0601 μM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50=92.6957 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=91.2676 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=90.54 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=89.8724 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=89.3741 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=85.7426 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=84.0208 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=84.0172 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=82.5893 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=81.8531 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=81.4368 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=81.344 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=80.9369 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=80.2857 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=80.1588 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=79.9553 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=78.5878 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=78.435 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=78.1299 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=77.0282 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=76.1096 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=75.8019 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=74.2528 μM | SANGER | ||
| RT4 | Growth Inhibition Assay | IC50=73.5742 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=73.5475 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=71.7415 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=71.4587 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=70.3 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=69.3961 μM | SANGER | ||
| C-4-II | Growth Inhibition Assay | IC50=69.3607 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=68.1171 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=67.0374 μM | SANGER | ||
| MFE-296 | Growth Inhibition Assay | IC50=64.4473 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=64.3035 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=64.2351 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=62.7126 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=62.2452 μM | SANGER | ||
| NCI-H1734 | Growth Inhibition Assay | IC50=61.9663 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=61.9242 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=61.4958 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=59.6487 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=59.6016 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=59.1587 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=59.0921 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=59.0553 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=57.5142 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=57.2412 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=56.6057 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=56.1693 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=56.0078 μM | SANGER | ||
| DV-90 | Growth Inhibition Assay | IC50=55.8917 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=55.8899 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=55.5066 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=54.8059 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=54.4364 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=54.1555 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=53.959 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=53.9381 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=53.6976 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=53.5169 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=52.145 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=51.9855 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=51.9785 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=51.8281 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=51.7554 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=51.5849 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=51.231 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=50.2225 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=49.8912 μM | SANGER | ||
| SNU-C1 | Growth Inhibition Assay | IC50=49.3207 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=48.973 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=48.4118 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=48.2982 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=47.7264 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=47.4589 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=46.8608 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=46.2031 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=46.0755 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=45.5898 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=45.3296 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=45.0437 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=44.2062 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=43.8673 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=43.7895 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=43.697 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=43.2099 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=42.6938 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=42.1801 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=41.9211 μM | SANGER | ||
| SK-CO-1 | Growth Inhibition Assay | IC50=41.7755 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=41.4473 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=40.5849 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=38.5998 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=38.4162 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=38.2575 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=38.1294 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=36.8444 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=36.3331 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=35.9294 μM | SANGER | ||
| EFE-184 | Growth Inhibition Assay | IC50=35.917 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=35.3416 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=35.1322 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=34.9241 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=33.7534 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=33.168 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=32.8467 μM | SANGER | ||
| HCC1143 | Growth Inhibition Assay | IC50=32.7979 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=32.7548 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=31.8662 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=31.7665 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=31.0047 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=30.9792 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=30.4965 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=30.2656 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=30.2059 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=29.7092 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=29.6828 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=29.6719 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=28.5326 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=28.0826 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=28.0052 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=27.9474 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=27.7907 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=27.7814 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=27.7728 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=27.5282 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=27.2565 μM | SANGER | ||
| SNG-M | Growth Inhibition Assay | IC50=27.2271 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=26.8986 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=26.7377 μM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=24.9328 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=24.835 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=24.2839 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=24.2163 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=24.0898 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=23.5486 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=23.1699 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=23.1132 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=22.7841 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=22.7069 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=22.6192 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=22.6068 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=22.2858 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=22.1954 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=21.8957 μM | SANGER | ||
| EoL-1- | Growth Inhibition Assay | IC50=21.8385 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=21.7035 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=21.6863 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=21.5354 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=20.3589 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=20.2169 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=20.1777 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=19.5342 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=19.243 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=18.715 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=18.6248 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=18.5305 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=17.9118 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=17.6149 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=16.6702 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=16.0097 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=15.2659 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=14.2251 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=14.1935 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=14.0116 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=13.7265 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=13.8829 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=13.5175 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=13.4717 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=13.3879 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=13.2909 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=13.2318 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=12.324 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=11.93 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=11.6579 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=11.1365 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=10.7235 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=10.6179 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=10.6102 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=10.4677 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=10.4413 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=9.99798 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=9.94444 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=9.7777 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=9.75566 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=9.65742 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=9.52397 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=9.45006 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=9.43894 μM | SANGER | ||
| COLO-205 | Growth Inhibition Assay | IC50=9.43821 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=9.42255 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=9.39986 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=9.30546 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=8.99043 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=8.88516 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=8.76113 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=8.54304 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=7.64584 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=7.46561 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=7.28691 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=7.16456 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=6.60936 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=6.53195 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=6.417 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=5.81509 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=6.38344 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=5.81266 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=5.72627 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=5.49145 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=5.45628 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=5.42456 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=4.9934 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=4.83858 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=4.70391 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=4.29479 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=4.13971 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=4.04545 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=3.96451 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=3.95343 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=3.88556 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=3.75498 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=3.48305 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=3.36054 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=3.0812 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=2.95485 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=2.7654 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=2.70193 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=2.64128 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=2.49787 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=2.27684 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=1.95415 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=1.78273 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=1.75977 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=1.72788 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=1.66898 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=1.30469 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=1.07912 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=0.94852 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=0.92131 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=0.8462 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.58832 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.58499 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=0.30672 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.21416 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Laduviglusib (CHIR-99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂，IC50为10 nM/6.7 nM。其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。CHIR-99021 是一种有效的药理性的 Wnt/beta-catenin 信号通路的激活剂。CHIR-99021 可显著地拯救光诱导的 autophagy，并可增强 GR，RORα和自噬相关蛋白等表达。 | ||||
|---|---|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | CHIR-99021作用于GSK-3比作用于其最接近的同系物CDC2和ERK2，及其他蛋白激酶选择性高500倍。此外，CHIR-99021只与一组22种药理相关的受体微弱结合，且对一组23种非激酶的酶几乎没有抑制活性。CHIR-99021作用于表达胰岛素受体的CHO-IR细胞，诱导糖原合成酶(GS)激活，EC50为0.763 μM。[1]CHIR-99021(3 μM)作用于3T3-L1前脂肪细胞，除了模拟胰岛素的作用，抑制GSK-3，使胞内游离β-catenin增加1.9倍，模仿经典Wnt信号通路。在分化的前3天，CHIR-99021处理，抑制脂肪细胞分化，IC50为0.3 μM，通过抑制CCAAT/增强子结合蛋白α（C/EBPα）和过氧化物酶体增殖物激活受体γ（PPARγ）的诱导作用。[2] 不像LiCl和AR-A014418，CHIR-99021处理，即使在高浓度，不会降低INS-1E细胞活力。相反，CHIR-99021增加INS-1E细胞增殖，这种作用具有剂量依赖性，且显著抑制高糖和高棕榈酸诱导的INS-E细胞死亡，这种作用具有浓度依赖性。CHIR-99021浓度低至1 μM，处理离体大鼠胰岛，促进β细胞复制，5 μM CHIR-99021处理，使细胞复制增长2-3倍。[3] |
|||
|---|---|---|---|---|
| 激酶实验 | 无细胞激酶实验 | |||
| 聚丙烯96孔板中每孔充满了含27 nM GSK-3α 或 29 nM GSK-3β, 和 0.5 μM 生物素-CREB 肽底物的300 μL 缓冲液 (50 mM Tris HCl, 10 mM MgCl2, 1 mM EGTA, 1 mM 二硫苏糖醇, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) 。各种浓度CHIR-99021加入3.5 μL DMSO中，随后加入50 μL ATP储存液，使所有无细胞实验中ATP终浓度为1 μM。温育后，100 μL等分试样按一式三份转移至每孔含100 μL 50 μM ATP和 20 mM EDTA的Combiplate 8孔板中。1小时后，使用用PBS将孔洗涤5次，填充200 μL闪烁液，密封，放置30分钟后，然后在闪烁计数器中计数。所有步骤在室温下进行。 | ||||
| 细胞实验 | 细胞系 | INS-1E | ||
| 浓度 | 溶于DMSO, 终浓度为20 μM | |||
| 孵育时间 | 1, 或 4 天 | |||
| 方法 | 细胞在饥饿培养基（只含5mM葡萄糖，1％胎牛血清）中维持24小时。然后使用不同浓度的CHIR-99021处理细胞的1天或4天。通过使用CyQuant染料进行细胞DNA染色，测量细胞数，当结合DNA就会发出荧光。温育30分钟后，使用FLUOstar Optima酶标仪测量荧光。通过BrdUrd掺入法测定细胞复制。最后4小时，BrdUrd标记溶液加入到培养基中，然后使用FixDenat溶液固定细胞，与单克隆anti-BrdUrd-POD抗体温育。每孔加入底物溶液后，在微孔板发光检测仪上使用Analyst HT检测系统测量光发射。 |
|||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | Cleaved PARP / CD31 / VE-Cadherin / α-SMA / vimentin CTNNB1 β-catenin |
|
30709379 | |
| Growth inhibition assay | Cell viability |
|
22039301 | |
| Immunofluorescence | SOX10 / EdU Oct3/4 |
|
28174705 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 |
CHIR-99021按30 mg/kg 剂量口服处理患2型糖尿病的啮齿类动物模型，增强葡萄糖代谢，处理3-4小时后，最大血浆葡萄糖减少近150 mg/dl，而血浆胰岛素保持或低于对照水平。CHIR-99021按16 或 48 mg/kg剂量口服给药ZDF大鼠，1小时后，再口服葡萄糖，显著改善糖耐量，16 mg/kg 和 48 mg/kg处理组的血浆葡萄糖分别减少14％和33％，较高剂量CHIR-99021处理，再口服葡萄糖，还可以降低高血糖。[1] |
|
|---|---|---|
| 动物实验 | Animal Models | 雌性db/db小鼠或雄性2型糖尿病ZDF大鼠 |
| Dosages | ~48 mg/kg | |
| Administration | 口服处理 | |
化学信息&溶解度
| 分子量 | 501.8 | 分子式 | C22H18Cl2N8.HCl |
| CAS号 | 1797989-42-4 | SDF | Download Laduviglusib (CHIR-99021) HCl SDF |
| Smiles | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 100 mg/mL ( (199.28 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 10 mg/mL Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
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如果有其他问题，请给我们留言。
* 必填项
常见问题及建议解决方法
问题 1:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
回答：
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
问题 2:
What is the difference between S2924 and S1263? Which one is better for differentiation?
回答：
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.
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