5-HT1
5-HT2
5-HT3
5-HT4
5-HT6
5-HT7
5-HT5

5-HT2 选择性抑制剂 | 激动剂 | 拮抗剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S2698	RS-127445	RS-127445 is a selective 5-HT2B receptor antagonist with pK_i of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.	Selective	5-HT2B, pIC50: 10.4; 5-HT2B, pKi: 9.5
S2232	Ketanserin	Ketanserin is a specific 5-HT2A serotonin receptor antagonist with K_i of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.	Selective	5-HT2C (Human), Ki: 100 nM; 5-HT2C (Rat), Ki: 50 nM; 5-HT2A, Ki: 2.5 nM
S8010	PRX-08066 Maleic acid	PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.	Selective	5-HT2B, IC50: 3.4 nM
S2112	Blonanserin	Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.	Selective	5-HT2, Ki: 3.98 nM
S4086	Loxapine Succinate	Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.	Selective	5-HT2 (bovine), Ki: 6.6 nM; 5-HT2 (bovine), Ki: 6.8 nM; 5-HT2 (human), Ki: 6.2 nM
S2459	Clozapine	Clozapine is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.	Selective
S2493	Olanzapine	Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.	Selective
S1243	Agomelatine	Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.	Selective
S1283	Asenapine	Asenapine is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.	Pan	5-HT2C, pKi: 10.46; 5-HT2B, pKi: 9.75; 5-HT2A, pKi: 10.15
S1615	Risperidone	Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.	Pan	5-HT2C, Ki: 12 nM; 5-HT2B, Ki: 61.9 nM; 5-HT2A, Ki: 0.17 nM
S4064	Escitalopram Oxalate	Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with K_i of 0.89 nM.	Pan	5-HT, Ki: 0.89 nM
S2663	WAY-100635 Maleate	WAY-100635 Maleate is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.87, exhibits >100-fold selectivity against other 5-HT receptor subtypes and major neurotransmitter receptors.	Pan	5-HT, IC50: 0.95 nM
S4053	Sertraline HCl	Sertraline HCl is a 5-HT antagonist with K_i of 13 nM.	Pan	5-HT, Ki: 13 nM
S2677	BRL-15572	BRL-15572 is a 5-HT1D receptor antagonist with pK_i of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.	Pan	5-HT2B, pKi: 7.4; 5-HT2C, pKi: 6.2; 5-HT2A, pKi: 6.6
S4113	Desvenlafaxine	Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.	Pan	5-HT, Ki: 40.2 nM
S4112	Desvenlafaxine Succinate	Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with K_i of 40.2 nM and 558.4 nM respectively.	Pan	5-HT, Ki: 40.2 nM
S3175	Atomoxetine HCl	Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with K_i of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.	Pan	5-HT, Ki: 77 nM
S3183	Amitriptyline HCl	Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.	Pan	5-HT2, IC50: 235 nM
S2691	BMY 7378	BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pK_i of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pK_i of 8.3.	Pan	5-HT2, pIC50: 5.5
S1333	Fluoxetine HCl	Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.	Pan
S1336	Fluvoxamine maleate	Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI).	Pan
S1869	Dapoxetine HCl	Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor.	Pan
S1432	Sumatriptan Succinate	Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.	Pan
S2084	Duloxetine HCl	Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor with K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).	Pan
S1245	Latrepirdine	Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.	Pan
S2016	Mirtazapine	Mirtazapine is a potent tetracyclic antidepressant.	Pan
S3005	Paroxetine HCl	Paroxetine HCl is an antidepressant drug of the SSRI type.	Pan
S2582	Trazodone HCl	Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.	Pan
S1441	Venlafaxine	Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.	Pan
S1483	Iloperidone	Iloperidone is an atypical antipsychotic for the treatment of schizophrenia.	Pan
S4244	Serotonin HCl	Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.	Pan
S1649	Zolmitriptan	Zolmitriptan is a selective serotonin receptor agonist.	Pan
S1488	Naratriptan	Naratriptan is a triptan agent that is used for the treatment of migraine headaches.	Pan
S2541	Clomipramine HCl	Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.	Pan