CXCL11 Rabbit Recombinant mAb

目录号：A5832

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20ul	447.52	现货
100ul	1500.69	现货
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使用信息

抗体应用

wb,ELISA

稀释比例

1:1000

反应性

Human

MW (kDa)

15kDa

抗体类型

Rabbit

浓度

1mg/ml

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

Datasheet & SDS

生物描述

特异性	CXCL11 Rabbit Recombinant mAb detects endogenous levels of total CXCL11
背景	The chemokine superfamily includes a large number of ligands that bind to a smaller number of receptors. Chemokines regulates the migration of various cells in the body and plays key roles in many disease processes, including inflammation, autoimmune disease, infectious diseases (such as HIV/AIDS), and cancer (in particular in regulating metastasis). The chemokines are small peptides, whereas their receptors are class A G-protein-coupled receptors. There are two main chemokine ligand superfamiles that are named CC family (the first two cysteines near the amino terminus are adjacent) and CXC family (there is one amino acid between two cysteines). The primary function of CXCL1-CXCL8 is regulation of neutrophil recruitment to inflammatory sites through interaction with CXCR1 and CXCR2. The main functions of the cytokines encoded in the MIP and MCP clusters of CC chemokines in human chromosome 17, which includes CCL1-CCL16, CCL18 and CCL23, is the recruitment of monocytes, subsets of T cells, eosinophils, and so on, to sites where inflammation is developing, through their interaction with CCR1, CCR2, CCR3 and/or CCR5. CXCL11 is known to be one of the early chemokines in inflammation. It mainly signals through CXCR3 and also binds to CXCR7

特异性

CXCL11 Rabbit Recombinant mAb detects endogenous levels of total CXCL11

背景

The chemokine superfamily includes a large number of ligands that bind to a smaller number of receptors. Chemokines regulates the migration of various cells in the body and plays key roles in many disease processes, including inflammation, autoimmune disease, infectious diseases (such as HIV/AIDS), and cancer (in particular in regulating metastasis). The chemokines are small peptides, whereas their receptors are class A G-protein-coupled receptors. There are two main chemokine ligand superfamiles that are named CC family (the first two cysteines near the amino terminus are adjacent) and CXC family (there is one amino acid between two cysteines). The primary function of CXCL1-CXCL8 is regulation of neutrophil recruitment to inflammatory sites through interaction with CXCR1 and CXCR2. The main functions of the cytokines encoded in the MIP and MCP clusters of CC chemokines in human chromosome 17, which includes CCL1-CCL16, CCL18 and CCL23, is the recruitment of monocytes, subsets of T cells, eosinophils, and so on, to sites where inflammation is developing, through their interaction with CCR1, CCR2, CCR3 and/or CCR5. CXCL11 is known to be one of the early chemokines in inflammation. It mainly signals through CXCR3 and also binds to CXCR7

实验方法

参考文献	[1] Albert Zlotnik, et al. Genome Biol. 2006, 7(12): 243. [2] Mitsuhashi N, et al. Mol Cell Biochem. 2007, 296(1-2):1-9. [3] Severin IC, et al. J Biol Chem. 2010, 285(23):17713-24.

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