| S8696 |
2-D08
|
2-D08 (2',3',4'-trihydroxy flavone) 是一种具有细胞透性的蛋白类泛素化（protein sumoylation）抑制剂。 |
-
Commun Biol, 2025, 8(1):1118
-
Int Immunopharmacol, 2025, 149:114187
-
Journal of General Physiology, 2025, e202513837
|
|
| S8829 |
Subasumstat (TAK-981)
|
Subasumstat (TAK-981)是一种新型的 SUMOylation enzymatic cascade 的选择性抑制剂，具有潜在的免疫激活和抗肿瘤活性。 |
-
Journal of Nanobiotechnology, June 18, 2024, 338
-
Nature Structural & Molecular Biology, July 20, 2023, 1303-1313
-
Frontiers in Cell and Developmental Biology, December 17, 2021, 741736
|
|
| S9432 |
Ginkgolic Acid
|
Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT). |
-
Microbiologyopen, 2025, 14(4):e70038
-
Pharmaceutics, 2024, 16(5)638
-
CNS Neurosci Ther, 2022, 10.1111/cns.13871
|
|
| S9159 |
momordin-Ic
|
Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo. |
-
Scientific Reports, 2025, 39054
-
International Journal of Molecular Sciences, 2022, 8282
-
Int J Mol Sci, 2022, 23(15)8282
|
|
| S4922 |
NSC 632839
|
NSC 632839不仅是一种DUB抑制剂，也是一种deSUMOylase抑制剂，作用于USP2， USP7，和SENP2， EC50分别为45 μM， 37 μM和9.8 μM。 |
|
|
| S9445 |
Ginkgolic Acid (C13:0)
|
Ginkgolic Acid (C13:0) 是银杏中的一种天然抗龋剂，对变形链球菌(S. mutans)具有抗菌活性，并能抑制与其致龋性相关的特定毒力因子。银杏酸是一种有效的 sumoylation 抑制剂，据报道可抑制 histone acetylation transferase (HAT) 。 |
|
|
| S8696 |
2-D08
|
2-D08 (2',3',4'-trihydroxy flavone) 是一种具有细胞透性的蛋白类泛素化（protein sumoylation）抑制剂。 |
- Commun Biol, 2025, 8(1):1118
- Int Immunopharmacol, 2025, 149:114187
- Journal of General Physiology, 2025, e202513837
|
|
| S8829 |
Subasumstat (TAK-981)
|
Subasumstat (TAK-981)是一种新型的 SUMOylation enzymatic cascade 的选择性抑制剂，具有潜在的免疫激活和抗肿瘤活性。 |
- Journal of Nanobiotechnology, June 18, 2024, 338
- Nature Structural & Molecular Biology, July 20, 2023, 1303-1313
- Frontiers in Cell and Developmental Biology, December 17, 2021, 741736
|
|
| S9432 |
Ginkgolic Acid
|
Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT). |
- Microbiologyopen, 2025, 14(4):e70038
- Pharmaceutics, 2024, 16(5)638
- CNS Neurosci Ther, 2022, 10.1111/cns.13871
|
|
| S9159 |
momordin-Ic
|
Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo. |
- Scientific Reports, 2025, 39054
- International Journal of Molecular Sciences, 2022, 8282
- Int J Mol Sci, 2022, 23(15)8282
|
|
| S4922 |
NSC 632839
|
NSC 632839不仅是一种DUB抑制剂，也是一种deSUMOylase抑制剂，作用于USP2， USP7，和SENP2， EC50分别为45 μM， 37 μM和9.8 μM。 |
|
|
| S9445 |
Ginkgolic Acid (C13:0)
|
Ginkgolic Acid (C13:0) 是银杏中的一种天然抗龋剂，对变形链球菌(S. mutans)具有抗菌活性，并能抑制与其致龋性相关的特定毒力因子。银杏酸是一种有效的 sumoylation 抑制剂，据报道可抑制 histone acetylation transferase (HAT) 。 |
|
|
