ALDH1A2 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 57kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | ALDH1A2 Rabbit Recombinant mAb detects endogenous levels of total ALDH1A2 |
|---|---|
| 背景 | The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH) genes, which encode enzymes critical for detoxification of endogenous and exogenous aldehyde substrates through NAD(P)+-dependent oxidation. ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, which are primarily localized in the cytosol of cells from various tissues, include enzymes able to oxidize retinal and aliphatic aldehydes. They exhibit high activity for oxidation of aldophosphamide and play a role in the detoxification of some commonly used anticancer drugs, such as oxazaphosphorines. ALDH1A2 is mainly distribute in Testis, liver and kidney. ALDH1A2 is a candidate tumor suppressor. Low ALDH1A2 expression is associated with an unfavorable prognosis in head and neck squamous cell carcinoma. |
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