Recombinant Human Noggin Protein, BSA (HEK293)

目录号: C0028

Recombinant Human Noggin Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Gln28-Cys232.

Recombinant Human Noggin Protein, BSA (HEK293)on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

规格	价格	库存
5ug	557	现货
10ug	890	现货
50ug	2570	现货
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使用信息

物种

Human

标签

His tag at the C-terminus.

来源

HEK293-drived human Noggin protein Gln28-Cys232.

预测分子量

25.7 kDa

实际分子量

28-38 kDa, reducing conditions

纯度

>95% as determined by Bis-Tris PAGE.

内毒素

< 0.1 EU/ug by the LAL method

制剂

Lyophilized from 0.22μm filtered solution in PBS with BSA as a carrier protein. Normally 8% trehalose is added as protectant before lyophilization.

储存条件 (自收到货起)

Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

生物描述

产品信息

Recombinant Human Noggin Protein (HEK293) 由 HEK293 表达，C 端带有 His 标签。其包含 Gln28-Cys232。

Accession

Q13253-1

别名

Noggin, NOG, SYM1, SYNS1

背景

Noggin是骨形态发生蛋白(BMP)的拮抗剂，对某些发育事件至关重要。在胃癌细胞系模型和癌症基因组图谱人类胃癌队列中，Noggin的表达与EGFR的表达呈正相关。靶向EGFR及其下游通路可抑制Noggin促进的细胞增殖。Noggin通过上调EGFR并增强β-catenin、EGFR、ERK和Akt形成的恶性循环来促进胃癌细胞的增殖。

参考文献

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