| S9785 |
Fatostatin
|
Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 |
-
Annals of Translational Medicine, September 29, 2022, 958
-
Cancer Research, October 1, 2024, 3250-3266
-
Drug Design, Development and Therapy, August 26, 2020, 3535-3545
|
|
| S4223 |
Mevastatin
|
Mevastatin (ML-236B,Compactin)是竞争性HMG辅酶A（HMG-COA）还原酶抑制剂，比HMG-CoA底物本身结合亲合力高10,000倍。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
ERJ Open Research, 2023, 00495-2022
-
Nat Cardiovasc Res, 2023, 2(6):550-571
|
|
| S4754 |
Betulin
|
Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. |
-
Journal of Pharmacology and Experimental Therapeutics, 30 July 2025, 103666
-
Frontiers in Oncology, 26 November 2021, 796152
-
Acta Biochim Biophys Sin -Shanghai), 2023, 55(9):1479-1486
|
|
| S6418 |
PF 429242
|
PF 429242是S1P抑制剂，IC50为170 nM。在其浓度高达100 μM时，PF 429242对胰蛋白酶、弹性蛋白酶、蛋白酶K、胞浆素、激肽释放酶、factor XIa、凝血酶或弗林蛋白酶没有显著抑制作用，而对尿激酶和factor Xa仅具有中等抑制作用。 |
-
Cell Rep, 2023, 42(6):112586
-
Nat Commun, 2019, 11;10(1):4621
|
|
| S5765 |
Sodium Dehydrocholate
|
Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion. |
|
|
| E0008 |
Atractylodin
|
Atractylodin (Atractydin) 是 Atractylodes lancea 根茎的主要成分之一，抑制 N-酰基乙醇胺水解酸酰胺酶 (NAAA) 的活性，IC50 为 2.81 µM。Atractylodin 还通过阻断 NPM-ALK 激活和 MAPK 来抑制白介素 6 (IL-6)。 |
|
|
| S5702 |
Fenipentol
|
Fenipentol (1-phenylpentan-1-ol, 1-Phenyl-1-pentanol, 1-Phenylpentanol) is a member of benzenes and stimulates plasma secretion & exocrine pancreatic secretion. |
|
|
| E5796 |
CAY10499
|
CAY10499 (MAGL-IN-5) 是一种非选择性脂肪酶抑制剂，其对人重组单酰甘油脂肪酶 (MAGL)的 IC₅₀ 值为 144 nM，对激素敏感性脂肪酶 (HSL)的 IC₅₀ 值为 90 nM，对脂肪酸酰胺水解酶 (FAAH)的 IC₅₀ 值为 14 nM。它还能抑制 MCF-7、MB-231、COV318、OVCAR-3 癌细胞系中的细胞生长。 |
|
|
| E1468 |
MSU-42011
|
MSU-42011 是一种口服活性retinoid X 受体 (RXR) 激动剂。 MSU-42011 抑制 iNOS 和 p-ERK 蛋白的表达。 它具有免疫调节和抗肿瘤活性。 MSU-42011 可用于癌症研究。 |
|
|
| S9168 |
Periplogenin
|
Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo. |
|
|
| S4930 |
Cetilistat
|
Cetilistat (ATL962)是一种高度亲脂性苯并恶嗪酮，抑制肠胃和胰脏脂酶（lipases）。在体内，它具有良好的安全性和耐受性。 |
|
|
| S9785 |
Fatostatin
|
Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 |
- Annals of Translational Medicine, September 29, 2022, 958
- Cancer Research, October 1, 2024, 3250-3266
- Drug Design, Development and Therapy, August 26, 2020, 3535-3545
|
|
| S4223 |
Mevastatin
|
Mevastatin (ML-236B,Compactin)是竞争性HMG辅酶A（HMG-COA）还原酶抑制剂，比HMG-CoA底物本身结合亲合力高10,000倍。 |
- J Immunother Cancer, 2024, 12(11)e009805
- ERJ Open Research, 2023, 00495-2022
- Nat Cardiovasc Res, 2023, 2(6):550-571
|
|
| S4754 |
Betulin
|
Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. |
- Journal of Pharmacology and Experimental Therapeutics, 30 July 2025, 103666
- Frontiers in Oncology, 26 November 2021, 796152
- Acta Biochim Biophys Sin -Shanghai), 2023, 55(9):1479-1486
|
|
| S6418 |
PF 429242
|
PF 429242是S1P抑制剂，IC50为170 nM。在其浓度高达100 μM时，PF 429242对胰蛋白酶、弹性蛋白酶、蛋白酶K、胞浆素、激肽释放酶、factor XIa、凝血酶或弗林蛋白酶没有显著抑制作用，而对尿激酶和factor Xa仅具有中等抑制作用。 |
- Cell Rep, 2023, 42(6):112586
- Nat Commun, 2019, 11;10(1):4621
|
|
| E0008 |
Atractylodin
|
Atractylodin (Atractydin) 是 Atractylodes lancea 根茎的主要成分之一，抑制 N-酰基乙醇胺水解酸酰胺酶 (NAAA) 的活性，IC50 为 2.81 µM。Atractylodin 还通过阻断 NPM-ALK 激活和 MAPK 来抑制白介素 6 (IL-6)。 |
|
|
| E5796 |
CAY10499
|
CAY10499 (MAGL-IN-5) 是一种非选择性脂肪酶抑制剂，其对人重组单酰甘油脂肪酶 (MAGL)的 IC₅₀ 值为 144 nM，对激素敏感性脂肪酶 (HSL)的 IC₅₀ 值为 90 nM，对脂肪酸酰胺水解酶 (FAAH)的 IC₅₀ 值为 14 nM。它还能抑制 MCF-7、MB-231、COV318、OVCAR-3 癌细胞系中的细胞生长。 |
|
|
| S4930 |
Cetilistat
|
Cetilistat (ATL962)是一种高度亲脂性苯并恶嗪酮，抑制肠胃和胰脏脂酶（lipases）。在体内，它具有良好的安全性和耐受性。 |
|
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