Isoliquiritigenin
中文名称：异甘草素
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。
Isoliquiritigenin Chemical Structure
CAS: 961-29-5
产品质控
批次：
纯度：
99.26%
99.26
Isoliquiritigenin相关产品
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细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| MCF7 cells | Cytotoxicity assay | 25-150 μM | 72 h | Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay | 18603336 |
| U937 cells | Function assay | 5 ug/ml | 24 h | Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control | 21866899 |
| dog MDCK cells | Function assay | 20 ug/mL | 1 h | Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control | 22743086 |
| U937 cells | Function assay | 5 ug/ml | Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control | 21866899 | |
| J774.1 cells | Function assay | 24 h | Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM | 15974608 | |
| colon 26-L5 cells | Cytotoxicity assay | 72 h | Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM | 18440233 | |
| human T47D cells | Function assay | 96 h | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 | |
| MCF7 cells | Function assay | 96 h | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay | 19928832 | |
| mouse NIH3T3 cells | Function assay | 8 h | Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM | 21112783 | |
| OE21 cells | Cytotoxicity assay | 72 h | Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM | 21696954 | |
| dog MDCK cells | Function assay | 8 h | Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence | 22743086 | |
| HUVEC | Cytotoxicity assay | 48 h | Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM | 25590864 | |
| K562 cells | Cytotoxicity assay | 48 h | Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM | 25590864 | |
| KB cells | Growth inhibition assay | Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM | 9767632 | ||
| MT-4 cells | Growth inhibition assay | Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM | 9767632 | ||
| Hepa lclc7 cells | Cytotoxicity assay | Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM | 18076142 | ||
| CHO cells | Cytotoxicity assay | Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM | 19572738 | ||
| MCF7 cells | Function assay | Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay | 19928832 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| NCI-H292 cells | Function assay | Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis | 22743086 | ||
| dog MDCK cells | Function assay | Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay | 22743086 | ||
| RBL-1 cells | Function assay | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM | 8254620 | ||
| PC3 cells | Cytotoxicity assay | Cytotoxicity against human PC3 cells, IC50=46.4 μM | 16441066 | ||
| Hepa-1c1c7 cells | Function assay | Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity | 12762787 | ||
| Hepa lclc7 cells | Function assay | Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity | 18076142 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 | ||
|---|---|---|---|
| 靶点 |
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| 体外研究(In Vitro) | ||||
| 体外研究活性 | Isoliquiritigenin通过抑制大鼠晶状体醛糖还原酶可能能够有效预防糖尿病并发症，IC50为320 nM，并且能够预防山梨糖醇在人类红细胞中的积累，IC50为2.0 μM。[1] Isoliquiritigenin通过抑制单酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白剂，IC50为8.1 μM。[2] 在DU145和LNCaP 细胞系中，Isoliquiritigenin诱导细胞周期停滞并抑制细胞生长。[3]在人类胃癌MGC-803细胞中， Isoliquiritigenin通过增加细胞内游离钙离子浓度，并降低线粒体膜电位(Deltapsi(m))而诱导细胞凋亡。[4] | |||
|---|---|---|---|---|
| 体内研究(In Vivo) | ||
| 体内研究活性 | LD50: 小鼠>6克/千克(灌胃) [5] | |
|---|---|---|
化学信息&溶解度
| 分子量 | 256.25 | 分子式 | C15H12O4 |
| CAS号 | 961-29-5 | SDF | Download Isoliquiritigenin SDF |
| Smiles | C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O | ||
| 储存条件(自收到货起) | |||
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体外溶解度 |
Ethanol : 26 mg/mL (101.46 mM) DMSO : 12 mg/mL ( (46.82 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : Insoluble |
摩尔浓度计算器 |
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体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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