| S2404 |
Isoliquiritigenin
|
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
-
J Nutr Biochem, 2024, 136:109808
-
Biomedicines, 2022, 10(3)638
-
Cancer Res, 2021, 81(16):4257-4274
|
|
| S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 |
-
Cell Rep Med, 2023, 4(6):101056
-
Free Radic Biol Med, 2021, 163:220-233
-
J Agric Food Chem, 2020, 68(42):11747-11757
|
|
| S5803 |
Alrestatin
|
Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 |
-
iScience, 2022, 25(4):104153
|
|
| S9196 |
Calceolarioside B
|
Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property. |
|
|
| S3245 |
Nodakenetin
|
Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素，可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达，并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。 |
|
|
| E2456 |
Soyasaponin Bb
|
Soyasaponin Bb是一种从Phaseolus vulgaris中分离出来的大豆皂苷，是一种醛糖还原酶 (aldose reductase, AKR1B1)差异抑制剂 (ARDI)。 |
|
|
| S1074 |
Poliumoside
|
Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 |
|
|
| S5446 |
2-Chloro-1-(4-fluorobenzyl)benzimidazole
|
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. |
|
|
| S9198 |
Obtusifolin
|
Obtusifolin is anthraquinone found in the seeds of Cassia obtusifolia, has inhibitory effects on platelet aggregation and aldose reductase. |
|
|
| S2404 |
Isoliquiritigenin
|
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
- J Nutr Biochem, 2024, 136:109808
- Biomedicines, 2022, 10(3)638
- Cancer Res, 2021, 81(16):4257-4274
|
|
| S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 |
- Cell Rep Med, 2023, 4(6):101056
- Free Radic Biol Med, 2021, 163:220-233
- J Agric Food Chem, 2020, 68(42):11747-11757
|
|
| S5803 |
Alrestatin
|
Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 |
- iScience, 2022, 25(4):104153
|
|
| S9196 |
Calceolarioside B
|
Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property. |
|
|
| S3245 |
Nodakenetin
|
Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素，可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达，并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。 |
|
|
| E2456 |
Soyasaponin Bb
|
Soyasaponin Bb是一种从Phaseolus vulgaris中分离出来的大豆皂苷，是一种醛糖还原酶 (aldose reductase, AKR1B1)差异抑制剂 (ARDI)。 |
|
|
| S1074 |
Poliumoside
|
Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 |
|
|
| S5446 |
2-Chloro-1-(4-fluorobenzyl)benzimidazole
|
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. |
|
|
| S9198 |
Obtusifolin
|
Obtusifolin is anthraquinone found in the seeds of Cassia obtusifolia, has inhibitory effects on platelet aggregation and aldose reductase. |
|
|
