Asunaprevir

别名: BMS-650032 中文名称:阿那匹韦

Asunaprevir是具有口服活性的HCV NS3抑制剂。HCV NS3是病毒复制蛋白加工所必需的蛋白酶。

Asunaprevir Chemical Structure

Asunaprevir Chemical Structure

CAS: 630420-16-5

规格 价格 库存 购买数量
10mM (1mL in DMSO) 2022.93 现货
2mg 794.51 现货
5mg 1777.89 现货
25mg 5381.51 现货
100mg 12858.96 现货
1g 49713.79 现货
更大包装 有超大折扣

400-668-6834

info@selleck.cn

免费分装
免费预溶

Asunaprevir相关产品

相关信号通路图

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
Huh7.5 replicon cells Antiviral assay 4 days Antiviral activity against HCV genotype 1b infected in human Huh7.5 replicon cells assessed as reduction in viral replication incubated for 4 days by luciferase reporter gene assay, EC50=0.006μM 29650290
HuH7.5 cells Antiviral assay 4 days Antiviral activity against HCV genotype 1b Con1 infected in human HuH7.5 cells assessed as inhibition of viral replication after 4 days by luciferase reporter gene assay, EC50=0.006μM 29456803
HuH7 replicon cells Function assay 4 days Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay, EC50=0.004μM 29162454
HuH7 replicon cells Function assay 4 days Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay, EC50=0.0012μM 29162454
HuH7 cells Antiviral assay 3 days Antiviral activity against HCV genotype 1b infected in human HuH7 cells co-treated with daclatasvir after 3 days by luciferase reporter assay 28430437
HuH7 cells Antiviral assay 3 days Antiviral activity against HCV genotype 1b infected in human HuH7 cells at >= 10 times antiviral EC50 after 3 days by luciferase reporter assay 28430437
genotype 2a replicon cells Function assay Inhibition of recombinant full length HCV genotype 3a S52 NS3 protease in genotype 2a replicon cells by luciferase reporter gene assay, EC50=1.1μM 27564532
genotype 2a replicon cells Function assay Inhibition of recombinant full length HCV genotype 2b HC-J8 NS3 protease in genotype 2a replicon cells by luciferase reporter gene assay, EC50=0.621μM 27564532
HCV replicon cells Antiviral assay Antiviral activity against HCV genotype 2a JHF-1 in HCV replicon cells assessed as reduction in viral RNA replication by luciferase reporter gene assay, EC50=0.217μM 27564532
HCV replicon cells Antiviral assay Antiviral activity against HCV genotype 1a H77 in HCV replicon cells assessed as reduction in viral RNA replication by luciferase reporter gene assay, EC50=0.004μM 27564532
Huh7.5 cells Antiviral assay Antiviral activity against HCV genotype 1b Con1 expressing NS3 protease infected in human Huh7.5 cells assessed as reduction in viral RNA replication by luciferase reporter gene assay, EC50=0.003μM 27564532
genotype 1b con1 replicon cells Function assay Inhibition of recombinant full length HCV genotype 4a ED43 NS3 protease in genotype 1b con1 replicon cells by luciferase reporter gene assay, EC50=0.0017μM 27564532
点击查看更多细胞系数据

生物活性

产品描述 Asunaprevir是具有口服活性的HCV NS3抑制剂。HCV NS3是病毒复制蛋白加工所必需的蛋白酶。
靶点
1b (J4L6S) [1] 1a (H77) [1] 6a (HK-6A) [1] 4a (ED43) [1] 5a (SA13) [1] 点击更多
0.3 nM 0.7 nM 0.9 nM 1.6 nM 1.7 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03208322 Withdrawn
Hepatitis C
Bristol-Myers Squibb
November 30 2018 --
NCT03004625 Completed
Hepatitis C
Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital
November 2016 Phase 3
NCT02865369 Unknown status
Chronic Hepatitis C
Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital
September 2016 --
NCT02580474 Completed
Hepatitis C
Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent''s Hospital Korea|Konkuk University Hospital|Cheongju St. Mary''s Hospital Cheongju Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|The Catholic University of Korea
February 2016 Phase 4
NCT02496078 Completed
Hepatitis C
Bristol-Myers Squibb
August 2015 Phase 3
NCT02309450 Withdrawn
Hepatitis C Virus Genotype 4 Infection
ANRS Emerging Infectious Diseases|Bristol-Myers Squibb
December 2014 Phase 2

化学信息&溶解度

分子量 748.29 分子式

C35H46ClN5O9S

CAS号 630420-16-5 SDF --
Smiles CC(C)(C)C(C(=O)N1CC(CC1C(=O)NC2(CC2C=C)C(=O)NS(=O)(=O)C3CC3)OC4=NC=C(C5=C4C=C(C=C5)Cl)OC)NC(=O)OC(C)(C)C
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 100 mg/mL ( (133.63 mM) ;DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 100 mg/mL (133.63 mM)

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

* 必填项

请输入您的姓名
请输入您的邮箱地址 请输入一个有效的邮箱地址
请写点东西给我们
Tags: buy Asunaprevir | Asunaprevir supplier | purchase Asunaprevir | Asunaprevir cost | Asunaprevir manufacturer | order Asunaprevir | Asunaprevir distributor
在线咨询
联系我们