BMS309403

BMS309403是FABP4小分子抑制剂,Kd值为4 nM,对FABP4的选择性比对FABP5和FABP3高100倍以上。

BMS309403 Chemical Structure

BMS309403 Chemical Structure

CAS: 300657-03-8

规格 价格 库存 购买数量
10mM (1mL in DMSO) 958.23 现货
5mg 794.93 现货
25mg 2596.89 现货
100mg 6306.75 现货
1g 31695.38 现货
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细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
THP1 Function assay 25 uM 3 days Reduction of transformation of human THP1 cells to foam cells at 25 uM after 3 days relative to control 17554340
aP2+/+ macrophage cells Function assay 25 uM Reduction in total cholesterol ester content in mouse aP2+/+ macrophage cells at 25 uM relative to control 17554340
aP2-/-R macrophage cells Function assay 25 uM Reduction in total cholesterol ester content in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in APOA1-mediated cholesterol in human THP1 cells at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in ABCA1 mRNA level in human THP1 cells at 25 uM relative to control 17554340
THP1 Function assay 25 uM Increase in ABCA1 protein level in human THP1 cells at 25 uM relative to control 17554340
aP2+/+ macrophage cells Function assay 25 uM Increase in cholesterol efflux in mouse aP2+/+ macrophage cells at 25 uM relative to control 17554340
aP2-/-R macrophage cells Function assay 25 uM Increase in cholesterol efflux in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control 17554340
aP2+/+ macrophage cells Function assay 24 hrs Decrease in MCP1 production in mouse aP2+/+ macrophage cells after 24 hrs 17554340
aP2-/-R macrophage cells Function assay 24 hrs Decrease in MCP1 production in mouse aP2-/-R macrophage cells (re-expression of aP2) after 24 hrs 17554340
BL21(DE3) Function assay Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay, Ki=0.22μM 27460668
BL21(DE3) Function assay Direct binding to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry, Kd=2.05μM 27460668
THP1 Function assay Reduction of Mcp1 expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of Mcp1 expression mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of Mcp1 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of IL1-beta expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of IL1-beta expressed in mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of IL1-beta expressed in mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of IL6 expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of IL6 expression mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of IL6 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
THP1 Function assay Reduction of TNF expression in human THP1 cells expressing aP2 relative to control 17554340
aP2+/+ macrophage cells Function assay Reduction of TNF expression in mouse aP2+/+ macrophage cells relative to control 17554340
aP2-/-R macrophage cells Function assay Reduction of TNF expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control 17554340
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生物活性

产品描述 BMS309403是FABP4小分子抑制剂,Kd值为4 nM,对FABP4的选择性比对FABP5和FABP3高100倍以上。
靶点
FABP4 [1]
(Cell-free assay)
4 nM(Kd)

化学信息&溶解度

分子量 474.55 分子式

C31H26N2O3

CAS号 300657-03-8 SDF --
Smiles CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5
储存条件(自收到货起) 3年 -20°C 粉状

体外溶解度
批次:

DMSO : 95 mg/mL ( (200.18 mM) ;DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 18 mg/mL (37.93 mM)

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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