BMS309403
BMS309403是FABP4小分子抑制剂，Kd值为4 nM，对FABP4的选择性比对FABP5和FABP3高100倍以上。
BMS309403 Chemical Structure
CAS: 300657-03-8
产品质控
批次：
纯度：
99.94%
99.94
BMS309403相关产品
| 相关化合物库 | 代谢化合物库 抗癌代谢化合物库 谷氨酰胺代谢化合物库 糖代谢化合物库 脂代谢化合物库 | 点击展开 |
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细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| THP1 | Function assay | 25 uM | 3 days | Reduction of transformation of human THP1 cells to foam cells at 25 uM after 3 days relative to control | 17554340 |
| aP2+/+ macrophage cells | Function assay | 25 uM | Reduction in total cholesterol ester content in mouse aP2+/+ macrophage cells at 25 uM relative to control | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 25 uM | Reduction in total cholesterol ester content in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in APOA1-mediated cholesterol in human THP1 cells at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in ABCA1 mRNA level in human THP1 cells at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in ABCA1 protein level in human THP1 cells at 25 uM relative to control | 17554340 | |
| aP2+/+ macrophage cells | Function assay | 25 uM | Increase in cholesterol efflux in mouse aP2+/+ macrophage cells at 25 uM relative to control | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 25 uM | Increase in cholesterol efflux in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control | 17554340 | |
| aP2+/+ macrophage cells | Function assay | 24 hrs | Decrease in MCP1 production in mouse aP2+/+ macrophage cells after 24 hrs | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 24 hrs | Decrease in MCP1 production in mouse aP2-/-R macrophage cells (re-expression of aP2) after 24 hrs | 17554340 | |
| BL21(DE3) | Function assay | Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay, Ki=0.22μM | 27460668 | ||
| BL21(DE3) | Function assay | Direct binding to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry, Kd=2.05μM | 27460668 | ||
| THP1 | Function assay | Reduction of Mcp1 expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of Mcp1 expression mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of Mcp1 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of IL1-beta expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of IL1-beta expressed in mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of IL1-beta expressed in mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of IL6 expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of IL6 expression mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of IL6 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of TNF expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of TNF expression in mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of TNF expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | BMS309403是FABP4小分子抑制剂，Kd值为4 nM，对FABP4的选择性比对FABP5和FABP3高100倍以上。 | ||
|---|---|---|---|
| 靶点 |
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化学信息&溶解度
| 分子量 | 474.55 | 分子式 | C31H26N2O3 |
| CAS号 | 300657-03-8 | SDF | -- |
| Smiles | CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5 | ||
| 储存条件(自收到货起) | 3年 -20°C 粉状 | ||
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体外溶解度 |
DMSO : 95 mg/mL ( (200.18 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 18 mg/mL (37.93 mM) Water : Insoluble |
摩尔浓度计算器 |
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体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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