Pyroptosis

亚型特异性产品

Pyroptosis产品

• 所有产品(5)
• Pyroptosis抑制剂 (4)
• Pyroptosis激活剂 (1)
• 新Pyroptosis产品

目录号	产品名	产品描述	文献引用	实验数据
S1680	Disulfiram	Disulfiram是一个特异性的乙醛脱氢酶 aldehyde-dehydrogenase (ALDH) 抑制剂，对hALDH1和hALDH2的IC50值分别0.15 μM和1.45 μM。Disulfiram 可用于治疗慢性酒精中毒，对酒精产生急性敏感性。Disulfiram 可诱导凋亡。Disulfiram 还是一种通过 gasdermin D (GSDMD) 作用的孔隙形成抑制剂。	Mol Cancer, 2024, 23(1):240 Bioact Mater, 2024, 36:238-255 Front Immunol, 2024, 15:1458270
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.	Redox Biol, 2024, 70:103039 Int J Oral Sci, 2024, 16(1):3 bioRxiv, 2024, 2024.03.19.585812
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK 是一种特异性的 inflammatory caspases 的抑制剂。Ac-FLTD-CMK 在体外通过 caspases-1、-4、-5 和 -11 抑制 gasdermin D (GSDMD) 裂解。Ac-FLTD-CMK 对caspases-1、caspases-4 和 caspases-5 的IC50值分别为 46.7 nM、1.49 μM 和 329 nM。	Cell Death Discov, 2024, 10(1):416 Biomolecules, 2022, 12(11)1660
S9622	LDC7559	LDC7559是一种有效的Gasdermin D(GSDMD)抑制剂，可抑制焦亡并减轻其炎症。	iScience, 2024, 27(5):109774 Heliyon, 2024, 10(11):e32571
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption.	RSC Adv, 2019, 9(3):1222-1229
S1680	Disulfiram	Disulfiram是一个特异性的乙醛脱氢酶 aldehyde-dehydrogenase (ALDH) 抑制剂，对hALDH1和hALDH2的IC50值分别0.15 μM和1.45 μM。Disulfiram 可用于治疗慢性酒精中毒，对酒精产生急性敏感性。Disulfiram 可诱导凋亡。Disulfiram 还是一种通过 gasdermin D (GSDMD) 作用的孔隙形成抑制剂。	Mol Cancer, 2024, 23(1):240 Bioact Mater, 2024, 36:238-255 Front Immunol, 2024, 15:1458270
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK 是一种特异性的 inflammatory caspases 的抑制剂。Ac-FLTD-CMK 在体外通过 caspases-1、-4、-5 和 -11 抑制 gasdermin D (GSDMD) 裂解。Ac-FLTD-CMK 对caspases-1、caspases-4 和 caspases-5 的IC50值分别为 46.7 nM、1.49 μM 和 329 nM。	Cell Death Discov, 2024, 10(1):416 Biomolecules, 2022, 12(11)1660
S9622	LDC7559	LDC7559是一种有效的Gasdermin D(GSDMD)抑制剂，可抑制焦亡并减轻其炎症。	iScience, 2024, 27(5):109774 Heliyon, 2024, 10(11):e32571
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption.	RSC Adv, 2019, 9(3):1222-1229
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.	Redox Biol, 2024, 70:103039 Int J Oral Sci, 2024, 16(1):3 bioRxiv, 2024, 2024.03.19.585812