| S1989 |
GABAA receptor agent 1 |
GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity. |
Selective |
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| S4494 |
Methionine |
Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity. |
Selective |
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| S3663 |
Afloqualone |
Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
Selective |
|
| S3634 |
6-Hydroxyflavone (6-HF) |
6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
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Selective |
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| S5049 |
Thiocolchicoside |
Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor. |
Selective |
|
| S7071 |
(+)-Bicuculline |
(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
Selective |
GABAA receptor, IC50: 2 μM |
| S3786 |
Glabridin |
Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
Selective |
α1β2γ2 (GABAA receptor), EC50: 6.3 μM; α1β3γ2 (GABAA receptor), EC50: 6.83 μM; α1β2 (GABAA receptor), EC50: 9.63 μM; α1β1γ2 (GABAA receptor), EC50: 17.23 μM |
| S5194 |
Furosemide sodium |
Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor. |
Selective |
|
| S2399 |
Dihydromyricetin |
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
Selective |
|
| S4197 |
Bemegride |
Bemegride(Bemegrid,3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning. |
Selective |
|
| S1332 |
Flumazenil (RO 15-1788) |
Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
Selective |
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