| S9478 |
Trans-4-Phenyl-3-buten-2-one |
Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite. |
Selective |
|
| S4255 |
Quinacrine 2HCl |
Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor. |
Selective |
|
| S7520 |
Darapladib |
Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.
|
Selective |
Lp-PLA2, IC50: 0.25 nM |
| S1110 |
Varespladib (LY315920) |
Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3. |
Selective |
hnsPLA2, IC50: 7 nM |
| S2364 |
Tanshinone I |
Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. |
Selective |
PLA2, IC50: 11 μM |
| S2390 |
Polydatin |
Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc. |
Selective |
|
| S9794 |
Melittin |
Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme. |
Selective |
|
| S4089 |
Halobetasol Propionate |
Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins. |
Selective |
|
| S4107 |
Clofazimine |
Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. |
Selective |
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