| S8860 |
Cintirorgon (LYC-55716) |
Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. |
Selective |
|
| S6610 |
GSK2981278 |
GSK2981278 is a highly potent and selective inverse agonist for RORγ. |
Selective |
|
| S3483 |
TMP778 |
TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay. |
Selective |
RORγt, IC50: 5 nM; RORγt, IC50: 17 nM |
| S0094 |
SR 0987 |
SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer. |
Selective |
RORγt, EC50: 800 nM |
| S6724 |
SR1001 |
SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. |
Pan |
RORγ, Ki: 111 nM |
| S5775 |
SR1078 |
SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist. |
Pan |
|
