| S6739 |
MN 64 |
MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively. |
Pan |
TNKS1, IC50: 6 nM |
| S1180 |
XAV-939 |
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. |
Pan |
TNKS1, IC50: 11 nM |
| S8876 |
RK-287107 |
RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM. |
Pan |
Tankyrase-1, IC50: 14.3 nM |
| S7239 |
G007-LK |
G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.
|
Pan |
TNKS1, IC50: 46 nM |
